Senior Director, HEOR & Evidence Strategy (Gene Editing)

Location: Remote role associated with Cambridge, Massachusetts, United States; up to 40% travel.

Salary: $289,601–$353,957 USD per year, plus performance-based annual bonus and equity compensation.

Company

hirify.global develops curative gene-editing treatments for severe and life-threatening diseases, including hereditary angioedema and transthyretin amyloidosis.

What you will do

• Own the integrated evidence generation plan and global HEOR strategy across clinical development, medical affairs, commercial strategy, pricing, reimbursement, and launch readiness.
• Lead evidence frameworks for one-time gene-editing therapies, including lifetime value, durability, long-term uncertainty, and novel endpoints.
• Direct cost-effectiveness models, budget impact models, scenario analyses, value narratives, global value dossiers, AMCP dossiers, and payer materials.
• Oversee real-world evidence, outcomes research, patient-reported outcomes, quality-of-life instruments, claims collaborations, and scientific communications.
• Build and lead the Field HEOR team, engage U.S. commercial, Medicare, and Medicaid payers, and present clinical, economic, and real-world evidence.
• Translate payer insights into evidence plans, value propositions, coverage strategies, utilization management approaches, and value-based agreement designs.

Requirements

• 10+ years of experience in HEOR, market access, or payer strategy within the pharmaceutical or biotechnology industry.
• At least 5 years of payer-facing HEOR or Field HEOR experience, or prior payer medical experience.
• Strong knowledge of payer decision-making, health economics methodologies, reimbursement systems, healthcare policy, and medical policy development.
• Experience developing or deploying payer launch deliverables and engaging directly with payers on clinical and economic evidence.
• Advanced degree or bachelor's degree plus advanced degree in health economics, outcomes research, public health, pharmacy, medicine, or a related field.
• Ability to lead teams, manage vendors and budgets, and collaborate with account teams, medical affairs, clinical development, regulatory, biostatistics, market access, and commercial functions.

Nice to have

• Experience in rare disease, cell therapy, gene therapy, or other advanced therapeutics.
• Experience supporting value-based contracting discussions and payer-focused real-world evidence collaborations.

Culture & Benefits

• Mission-driven environment focused on developing curative therapies for severe diseases.
• Culture centered on exploring, disrupting, delivering, and maintaining high scientific standards.
• Remote work arrangement with travel for partner meetings, conferences, and internal cross-functional workshops.
• Performance-based annual cash bonus, new-hire equity grant, and eligibility for annual equity awards.

Hiring process

• Applications are accepted on a rolling basis until the position is filled.