Analytical Chemistry Scientist (DMPK)

Location: Onsite in Emeryville, California, United States

Salary: $135,000–$155,000 annual salary, depending on experience

Company

hirify.global is a clinical-stage drug discovery company developing therapeutics for protein misfolding diseases, rare diseases, and oncology through its Navigator platform combining synthetic biology, generative chemistry, and AI/ML.

What you will do

• Develop and implement high-throughput DMPK assays suitable for machine learning methods.
• Develop and deploy chromatographic and mass spectrometric methodologies, including reversed-phase, HILIC, SFC, and 2D-LC/MS separations.
• Design, optimize, and troubleshoot LC-MS/MS and UHPLC methods covering sample preparation, separation, and data interpretation across complex biological matrices.
• Develop computational approaches for interpreting complex analytical data using R, Python, command-line tools, and statistical methods.
• Present findings to internal and external project teams.
• Collaborate with machine learning scientists, software engineers, biologists, chemists, and automation engineers.

Requirements

• PhD in Analytical Chemistry, Biochemistry, Chemistry, Chemical Biology, or a related discipline.
• 3–5 years of post-PhD experience in analytical or bioanalytical research.
• Deep technical expertise with HPLC, UPLC, LC-MS, CAD/MS, spectroscopy, and related analytical instrumentation.
• Hands-on chromatographic method development across reversed-phase, normal-phase, HILIC, SEC, SFC, and 2D-LC/MS modes.
• Strong familiarity with DMPK and small-molecule drug discovery, plus experience analyzing complex chromatographic datasets.
• Experience with R or Python, laboratory automation platforms, and high-throughput screening methods.

Nice to have

• Industry experience in analytical or bioanalytical research.
• Experience with EchoMS and BBB assay development.
• Experience with SciexOS, Xcalibur, MassHunter, Chromeleon, Virscidian, or Skyline.
• A paper, preprint, or software repository demonstrating relevant work.

Culture & Benefits

• Collaborative, fast-paced, and interdisciplinary research environment.
• Opportunity to work on the Navigator platform and drug discovery programs.
• Medical, dental, and vision benefits.
• Equity and 401(k) matching.
• Inclusive and supportive workplace that values varied backgrounds and equivalent combinations of experience.