Associate Director, Pharmacology (AI Pharma)

Location: Hybrid, requiring 3 days per week in office in the Boston or New York City metro areas; applicants in the Research Triangle, NC, and San Francisco Bay Area may also be considered. Applicants must reside in these locations or be willing to relocate.

Compensation: $177,500–$232,000 annually, plus equity, comprehensive benefits, and perks.

Company

hirify.global is a technology- and AI-driven pharmaceutical company developing medicines more efficiently through drug development platforms, processes, and capabilities.

What you will do

• Execute and contribute to preclinical pharmacology strategies across development programs, primarily through CROs.
• Design, oversee, and interpret studies covering mechanism of action, target biology, in vivo proof of concept, dose response, pharmacodynamic activity, and exposure-response relationships.
• Develop integrated plans covering efficacy, target engagement, receptor binding, selectivity, biomarkers, PK/PD, translational hypotheses, safety margins, therapeutic index, and dose rationale.
• Apply first-principles reasoning to evaluate biological rationale, test assumptions, and design decision-critical studies.
• Partner with DMPK, Toxicology, Clinical Pharmacology, Clinical Development, Regulatory, CROs, and external partners.
• Manage CRO studies and workflows, including protocols, vendors, data quality, budgets, timelines, reports, modeling, analytics, literature mining, and AI-enabled tools.

Requirements

• PhD in Pharmacology, Biology, Immunology, Translational Sciences, or a related field.
• 4–6+ years of relevant post-PhD biopharma industry experience.
• Hands-on expertise in preclinical pharmacology, including mechanism of action, disease biology, in vivo efficacy models, dose response, target engagement, biomarkers, selectivity, and PK/PD.
• Experience designing, overseeing, and interpreting animal studies, including model selection, endpoints, dosing rationale, exposure-response relationships, and translational limitations.
• Experience developing pharmacology strategies for candidate selection, IND-enabling work, clinical development, lifecycle management, regulatory submissions, or externally sourced assets.
• Strong scientific judgment, communication, organization, collaboration, and cross-functional CRO study management skills.

Nice to have

• Familiarity with immunology, immune-mediated disease biology, or immunomodulatory mechanisms.
• Experience using technology, modeling, data analytics, and AI-enabled approaches in pharmacology research.

Culture & Benefits

• Hybrid work model with office collaboration three days per week.
• Equity compensation in addition to base salary.
• Comprehensive benefits and generous perks.
• Collaborative, fast-paced environment focused on rigorous and efficient drug development.