Director/Senior Director, In Vivo Pharmacology (Oncology)

Location: San Francisco, California; on-site

Salary: $195,000–$290,000 annually, plus eligibility for an annual discretionary bonus and equity incentive plan.

Company

hirify.global is a biopharma company developing a disease-agnostic, fully integrated network biology platform using genetics, proteomics, structural biology, and AI to advance drug discovery.

What you will do

• Lead in vivo pharmacology strategy for small-molecule oncology programs.
• Design and oversee CDX, PDX, and syngeneic in vivo studies, including model selection, dose and schedule optimization, PK/PD integration, and efficacy assessment.
• Develop pharmacology plans supporting development candidate nomination, IND readiness, and early clinical translation.
• Integrate tumor efficacy, exposure, pharmacodynamic biomarkers, tolerability, and mechanism-of-action data to guide compound prioritization and program decisions.
• Collaborate with biology, medicinal chemistry, DMPK, and external CRO partners.
• Mentor and potentially manage scientists as the organization grows.

Requirements

• PhD in pharmacology, cancer biology, molecular biology, physiology, translational medicine, or a related discipline.
• Typically 10+ years of relevant industry experience in oncology drug discovery or translational pharmacology.
• Deep expertise in in vivo pharmacology for small-molecule oncology drug discovery.
• Experience designing and interpreting efficacy, PK/PD, dose-response, dose-scheduling, and mechanism-of-action studies in oncology models.
• Hands-on experience with rodent oncology models, including CDX, PDX, and syngeneic models.
• Experience integrating pharmacology with medicinal chemistry, DMPK, biomarker strategy, candidate nomination, and CRO oversight.

Culture & Benefits

• Collaborative workplace focused on respect, diversity, team science, and shared success.
• Medical, dental, and vision insurance.
• Discretionary time off, company holidays, and summer and winter shutdowns.
• 401(k), commuter or mass transit benefits, and healthcare and dependent care FSAs.
• Parental leave and a flexible work schedule.