Associate Director - Director, In Vivo Pharmacology

Location: Emeryville, California, United States; on-site

Salary: $200,000–$260,000 USD annually

Company

hirify.global is an AI biology company building foundation models for biological molecules and developing AI-designed gene editing medicines.

What you will do

• Lead in vivo pharmacology strategy for customized base editor programs across rodent and non-human primate studies, from proof of concept through candidate nomination and IND-enabling planning.
• Design and oversee studies assessing editing efficiency, delivery, biodistribution, exposure, dose response, durability, pharmacodynamic biomarkers, tolerability, and translational relevance.
• Represent in vivo pharmacology on cross-functional teams and translate complex datasets into recommendations for candidate selection, dose rationale, and development strategy.
• Manage external CRO and vivarium execution, including protocols, vendor oversight, monitoring, sample logistics, data quality control, troubleshooting, and report review.
• Integrate NGS, ddPCR/qPCR, RNA and protein, histology, clinical chemistry, cytokine, immunology, and other study readouts with partner teams and CROs.
• Build scalable pharmacology processes and contribute to regulatory-facing packages while mentoring researchers.

Requirements

• PhD or equivalent in pharmacology, physiology, molecular biology, genetics, bioengineering, or a related field, plus 6–8 years of relevant industry experience.
• Experience designing, managing, and interpreting rodent and non-human primate pharmacology studies and supporting IND-enabling studies.
• Experience with genetic medicines, including genome editing, base editing, gene therapy, RNA medicines, oligonucleotides, LNP delivery, or viral vectors.
• Strong understanding of PK/PD, dose response, biodistribution, target engagement, pharmacodynamic biomarkers, translational endpoints, and preclinical development strategy.
• Experience leading CRO studies and operating as a senior cross-functional scientific leader.
• Applicants must already have ongoing United States work authorization that does not require employer sponsorship.

Culture & Benefits

• Competitive compensation with equity participation.
• 401(k) with a strong employer match.
• Health, dental, and vision insurance.
• Generous paid time off and a commitment to work-life balance.
• Professional development in the AI and biology field.