Chief Medical Officer (CMO)

Location: South San Francisco, California, United States. The role is either onsite approximately 3 days per week or hybrid with onsite presence for 1–2 weeks per month.

Salary: $450,000–$480,000 per year, plus annual performance bonus and equity incentive plan eligibility.

Company

hirify.global is a physical AI drug discovery and development company using machine learning, multimodal biological data, and human genetics to develop therapeutics and clinical strategies.

What you will do

• Architect and lead the end-to-end clinical development strategy across therapeutic areas and modalities.
• Build, scale, and mentor a clinical development organization spanning medical, translational, biomarker, safety, regulatory, and clinical operations functions.
• Design and oversee clinical trial protocols, Investigator Brochures, clinical development plans, and ongoing trial execution.
• Develop AI-powered adaptive, basket, and Bayesian trial methodologies to optimize patient stratification, dosing, and operational efficiency.
• Lead Medical Affairs, Pharmacovigilance, Regulatory Affairs, patient safety, and interactions with agencies including the FDA and EMA.
• Provide clinical and strategic guidance across target validation, indication selection, late-stage development, partnerships, investor communications, and post-marketing activities.

Requirements

• MD or equivalent degree with board certification in a therapeutically relevant area.
• 20+ years of progressive clinical development experience in the pharmaceutical or biotechnology industry.
• Proven record of successful IND and NDA/BLA submissions and significant strategic involvement in an approved New Chemical Entity.
• Direct experience designing and delivering Phase 1 and Phase 2 trials, establishing human proof of concept, and applying biomarkers and adaptive trial designs.
• Deep knowledge of global regulatory requirements and successful collaboration with regulatory agencies.
• Experience applying AI/ML and data science methods in clinical trials, biomarker discovery, regulatory submissions, or clinical operations.
• Experience building high-performance teams and working across large biopharma organizations and agile startups.

Nice to have

• Experience in metabolic disease or neuroscience.
• Board certification or therapeutic expertise in cardiometabolic disease or neuroscience.
• Experience communicating with investors and collaborating with academic institutions and key opinion leaders.

Culture & Benefits

• Annual performance bonus plan and equity incentive plan.
• 401(k) plan with employer matching and medical, dental, vision, and mental health coverage.
• Flexible vacation policy and paid parental leave.
• Quarterly budget for books and online courses, plus a home-office setup stipend.
• Monthly cell phone and internet stipend, onsite meals and baristas, and commuter bus access across the Bay Area.