Lead Bioinformatician (cfDNA Algorithms and Pipelines)

Location: San Carlos, California, United States; onsite role

Salary: $144,000–$180,000 USD base pay, plus additional compensation and benefits.

Company

hirify.global develops cell-free DNA testing and personalized genetic diagnostics for oncology, women’s health, and organ health.

What you will do

• Contribute genomics algorithm expertise to assay and panel roadmaps, including difficult genes and edge cases.
• Define computational strategies for targeted and special-purpose variant callers, prototype and benchmark methods, and support production implementation.
• Investigate complex production escalations across biological, analytical, and pipeline causes, converting findings into durable rules and design improvements.
• Partner with Variant Management, Reporting, Laboratory Operations, Product, Research, Engineering, and Laboratory Directors on data quality and method deployment.
• Help establish appropriate boundaries and human review requirements for AI-assisted scientific investigations.

Requirements

• Degree in Bioinformatics, Computational Biology, Human Genetics, or a related field, or equivalent professional depth.
• At least 4 years of substantially independent experience analyzing short-read sequencing data for screening or diagnostic applications.
• Experience contributing to bioinformatics workflows supporting a sequencing assay or panel.
• Experience developing, validating, or benchmarking methods for SNVs, CNVs, SVs, or other difficult variant classes.
• Proficiency in Python and experience prototyping bioinformatics tools or variant callers.
• Experience taking complex investigations through biological, analytical, and systems-level resolution.

Nice to have

• Experience with non-invasive prenatal testing, reproductive screening, carrier screening, or cfDNA.
• Algorithm development experience across short-read and long-read platforms such as Illumina, ONT, or PacBio.
• Experience in accredited or high-complexity laboratories and production support or escalation processes.
• Cross-functional experience with genetic counseling, variant management, reporting, and production-adjacent groups.

Culture & Benefits

• Individual contributor role within a multidisciplinary group of statisticians, geneticists, physicians, laboratory scientists, and software engineers.
• Annual performance incentive bonus and long-term equity awards.
• Medical, dental, vision, life, and disability coverage, including benefits for eligible dependents.
• 401(k) with company match, paid time off, company holidays, commuter benefits, and wellness programs.
• Additional fertility care, pregnancy, and baby bonding benefits.