Principal Scientist (Computational Chemistry)

TL;DR

Principal Scientist (Computational Chemistry): Leading the discovery and optimization of induced proximity small molecules using advanced computational science and AI/ML technologies with an accent on ternary complex modeling and affinity prediction. Focus on implementing generative models, molecular dynamics, and collaborating with cross-functional teams to accelerate the clinical candidate pipeline.

Location: South San Francisco, California, USA

Salary: $144,900 - $269,100

Company

hirify.global, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases.

What you will do

• Lead the development and implementation of advanced computational methods, including molecular dynamics and affinity prediction for ternary complex modeling and ligand discovery.
• Apply advanced AI/ML technologies, including protein-ligand co-folding and generative/active learning models, in collaboration with the AI for Drug Discovery team.
• Provide strategic direction and present scientific findings to internal and external stakeholders, including wet-lab scientists.
• Collaborate cross-functionally with Structural Biology, Biochemical Pharmacology, DMPK, and Safety/Investigational Toxicity groups.
• Foster a collaborative environment within project teams to ensure computationally informed and driven decisions.

Requirements

• Ph.D. in Computational Chemistry, Biophysics, or a related field.
• 0-6 years of relevant post-Ph.D. experience in industry or a research organization.
• Proven track record of induced proximity discovery or design projects.
• Deep knowledge of computational chemistry principles and general molecular modeling techniques (docking, simulation, dynamics, quantum mechanics).
• Proficiency in Python or other relevant programming languages.
• Experience with cloud computing platforms and/or high-performance computing (HPC) environments.

Nice to have

• Familiarity with computational software such as MOE, Schrodinger, OpenEye, and/or Rosetta.
• Experience in AI/ML applications specifically in the induced proximity space.
• Strong track record of publication in leading scientific journals and presentations at major conferences.

Culture & Benefits

• Relocation benefits are available for this position.
• Discretionary annual bonus based on individual and company performance.
• Comprehensive health and wellness benefits package.
• Opportunity to work in a pioneering biotechnology environment dedicated to solving complex health challenges.