Principal Scientist, Drug Substance and Process Science (Biotech)

TL;DR

Principal Scientist, Drug Substance and Process Science (Biotech): Driving innovation in cell therapy technologies and implementing robust CAR-T processes for GMP manufacturing with an accent on cell starting material characterization and isolation technologies. Focus on elucidating dependencies between starting materials and drug product quality and developing technical strategies for clinical and commercial manufacturing.

Location: Onsite in South San Francisco, CA. Candidates must be authorized to work in the U.S.

Salary: $155,000 - $180,000 per year

Company

hirify.global is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T) products for cancer and autoimmune diseases.

What you will do

• Lead the design and execution of high-impact Cell Starting Material characterization studies using QbD principles.
• Evaluate and develop innovative cell isolation technologies and technical strategies aligned with program objectives.
• Drive process understanding and control strategy development to support clinical and commercial manufacturing.
• Serve as a subject matter expert (SME) in cell therapy process sciences, providing scientific and technical leadership.
• Collaborate cross-functionally with R&D, Analytical Sciences, MSAT, Quality, and Regulatory teams.
• Act as a technical mentor, coaching scientists on study design, data interpretation, and scientific decision-making.

Requirements

• Ph.D. in Molecular & Cell Biology, Immunology, or related field (7+ years exp), or MS (10+ years), or BS (12+ years).
• Expertise in immunology, cellular biology, aseptic technique, and cell-based assays.
• Experience in cell isolation and enrichment from biological sources and optimizing cryopreservation processes.
• Strong understanding of cell therapy manufacturing (gene editing, viral transduction, cell expansion, formulation).
• Proven track record of leading complex technical programs and cross-functional initiatives.
• Must be authorized to work in the U.S.

Culture & Benefits

• Annual performance bonus and equity.
• Comprehensive health insurance and generous time off.
• Two annual company-wide holiday shutdowns.
• Collaborative work environment with high-caliber scientific talent.