Principal Scientist (Immunology)

TL;DR

Principal Scientist (Immunology): Leading clinical biomarker strategy and translational research for novel cell therapies in hematological malignancies with an accent on mechanism of action (MOA) studies. Focus on designing clinical studies, analyzing high-dimensional molecular data, and bridging discovery with clinical development to advance immuno-oncology programs.

Location: Must be based in or able to commute to Somerset, New Jersey, USA (Hybrid role).

Salary: $146,410 - $192,164 USD

Company

A global biotechnology company developing advanced cell therapies, including CAR-T and TCR-T, to treat life-threatening diseases.

What you will do

• Design and execute clinical studies to investigate mechanisms of action for novel IO targets in hematological indications.
• Bridge discovery and clinical development by validating targets using primary human samples and clinical datasets.
• Oversee the interpretation of high-dimensional molecular data, including scRNA-seq, to profile immune cell compartments.
• Serve as the biology lead on cross-functional project teams to drive clinical biomarker strategy.
• Partner with functional teams to deepen the understanding of fundamental immunology and MOA.

Requirements

• Ph.D. in Immunology, Immuno-Oncology, Cellular Biology, or a closely related discipline.
• Minimum of 5-8+ years of post-doctoral or industry experience in biotech/pharma.
• Deep biological understanding of hematological malignancies and the tumor immune microenvironment.
• Proven track record of advancing IO programs and extracting biological insights from multi-dimensional data.
• Exceptional communication skills for distilling complex data into actionable strategic decisions.

Culture & Benefits

• Comprehensive medical, dental, and vision insurance.
• 401(k) retirement plan with company match vesting on day one.
• Eight weeks of paid parental leave after three months of employment.
• Generous paid time off policy including vacation, sick time, and eleven company holidays.
• Access to well-being initiatives, family planning resources, and peer-to-peer recognition programs.