Product Policy Biosecurity Policy Manager (Biosecurity)

TL;DR

Product Policy Biosecurity Policy Manager (Biosecurity): Guide how OpenAI evaluates, launches, and governs biology and life-sciences capabilities with an accent on translating dual-use biological misuse risk into practical product policy, access criteria, and enforcement guidance. Focus on building scalable policy frameworks, operationalizable standards and escalation paths, and improving safeguards using evals, red-team findings, and production signals.

Location: San Francisco

Salary: $261K – $290K + Offers Equity

Company

OpenAI develops and deploys general-purpose AI systems with a focus on safety and responsible use.

What you will do

• Provide biosecurity and life-sciences policy advice to product and technical teams based on model capabilities, biological R&D workflows, and abuse pathways.
• Evaluate bio-relevant product launches and capabilities for beneficial use cases (public health, clinical education, drug discovery) and potential misuse by malicious actors.
• Translate biological misuse risk into product requirements, launch guidance, enforcement standards, user-facing policy, internal implementation guidance, and reviewer SOPs.
• Define scalable policy frameworks for dual-use biological capabilities, including boundaries between broadly beneficial assistance, higher-risk support, and restricted/disallowed activity.
• Develop operationalizable standards, enforcement protocols, and escalation paths for bio-misuse scenarios, including suspicious dual-use trajectories and account/organization-level misuse patterns.
• Design trusted access frameworks for higher-capability biological systems (actor vetting, institutional legitimacy, access scoping, re-verification, and escalation obligations) and improve policy quality using evals, red-team findings, and operational data.

Requirements

• 7+ years of experience (or equivalent depth) in biosecurity, biosafety, life sciences R&D, synthetic biology, molecular biology, computational biology, public health, biodefense, or biological risk management, plus product policy/trust & safety/abuse investigations or a closely related field.
• Strong technical fluency in one or more biological or biosecurity domains (e.g., synthetic biology, molecular biology, genomics, bioinformatics, protein engineering, lab automation, pathogen surveillance, sequence screening, institutional biosafety, biological threat assessment, life-sciences research governance).
• Ability to evaluate dual-use biological capabilities with nuance, distinguishing legitimate work, lower-risk educational/analytical assistance, ambiguous cases, irresponsible activity, and harmful misuse.
• Ability to reason about risk using actor, environment, and trajectory (who the user is, what institution/governance they operate under, and behavior patterns over time).
• Comfort turning ambiguous scientific and security questions into practical policy frameworks, access criteria, taxonomies, review rubrics, launch recommendations, and operational guidance.
• Clear communication with product managers, engineers, researchers, executives, safety/security practitioners, and external life-sciences and policy stakeholders.

Culture & Benefits

• Work in a fast-moving, ambiguous environment at the intersection of AI capability, life sciences practice, biosecurity, biosafety, and abuse prevention.
• Cross-functional collaboration with product, engineering, research, safety, security, legal, operations, global affairs, and go-to-market teams.
• Compensation includes $261K–$290K plus offers equity.
• Equal opportunity employer with background checks administered in accordance with applicable law.