Lead Bioinformatics & Machine Learning Scientist (Epigenomics)

Location: US Remote; United States

Salary: $146,000–$180,000 USD annually

Company

hirify.global develops cell-free DNA testing and personalized genetic diagnostics for oncology, women’s health, and organ health.

What you will do

• Lead technical workstreams from problem definition through delivery of final classifiers for downstream validation.
• Design, implement, and validate machine learning and statistical methods for cancer diagnostics.
• Build feature engineering and extraction pipelines for cfDNA methylation and sequencing data.
• Establish practices for model interpretability, uncertainty estimation, reproducibility, and data quality control.
• Collaborate with molecular biologists on experimental design and lead code and design reviews.
• Mentor scientists and provide technical leadership within a collaborative research team.

Requirements

• PhD in Bioinformatics, Computer Science, Machine Learning, Statistics, or a related quantitative field, with 4 to 8+ years of post-PhD experience.
• Hands-on experience in cancer genomics or epigenomics.
• Strong quantitative reasoning, statistical analysis, and applied machine learning skills.
• Proven experience developing computational methods for high-throughput sequencing data analysis.
• Strong programming skills with Python and its scientific library stack, including pandas, NumPy, and scikit-learn.
• Experience with Linux command-line tools, shell scripting, Git, workflow managers such as Nextflow or Snakemake, and cloud or HPC compute environments.
• Ability to conduct hypothesis-driven research, visualize findings, and communicate results orally and in writing.
• Experience mentoring or technically leading other scientists.

Nice to have

• Experience with cell-free DNA or methylation sequencing data.
• Experience with deep learning frameworks.

Culture & Benefits

• Collaborative environment focused on innovation, scientific excellence, and inclusive teamwork.
• Comprehensive medical, dental, vision, life, and disability plans for eligible employees and dependents.
• Free testing for employees and immediate family members, plus fertility care benefits.
• Pregnancy and baby bonding leave, 401(k) benefits, commuter benefits, and an employee referral program.