Director / Senior Director, DMPK

Location: Hybrid, requiring 3 days per week in the office, primarily in the Boston or New York City metro areas; applicants in the Research Triangle or San Francisco Bay Area may also be considered. Applicants must reside in these locations or be willing to relocate.

Total compensation range: $245,500–$388,500, including Director and Senior Director ranges. Base salary, equity, benefits, and perks are included in the compensation package.

Company

hirify.global is a technology- and AI-driven pharmaceutical company developing medicines more efficiently through technology platforms, drug development capabilities, and clinical-trial processes.

What you will do

• Lead DMPK scientific diligence for potential in-licensing, acquisition, and partnership opportunities across therapeutic areas and development stages.
• Evaluate nonclinical and clinical PK, ADME, metabolism, transporters, bioavailability, PK/PD, exposure-response, DDI, organ impairment, formulation, and absorption data.
• Identify data gaps, inconsistencies, material development risks, mitigations, and priority experiments or analyses for diligence and portfolio decisions.
• Provide DMPK leadership for advanced preclinical and clinical programs, including strategy from late preclinical development through IND/CTA and clinical development.
• Lead human PK prediction and nonclinical-to-clinical PK/PD translation to support first-in-human dose selection, dose escalation, and dose optimization.
• Partner with Clinical Pharmacology, Pharmacometrics, Clinical Development, Toxicology, CMC, regulatory functions, CROs, consultants, and external partners.

Requirements

• PhD in pharmaceutical sciences, pharmacokinetics, pharmacology, chemistry, biochemistry, or a related discipline, with typically 8+ years of relevant biotechnology or pharmaceutical industry experience, or an equivalent combination of education and experience.
• Deep DMPK expertise with substantial experience supporting development-stage small-molecule programs.
• Experience integrating nonclinical and clinical PK data to guide drug-development decisions.
• Strong knowledge of ADME, clearance mechanisms, drug metabolism, transporters, absorption, bioavailability, protein binding, tissue distribution, and drug-drug interactions.
• Experience with human PK prediction, PK/PD, exposure-response analysis, and clinical translation.
• Experience supporting IND-enabling development and clinical-stage programs.
• Strong working knowledge of regulatory expectations for DMPK and clinical pharmacology during drug development.
• Experience evaluating complex, incomplete, inconsistent, or evolving datasets and making recommendations.
• Ability to work effectively with external CROs, consultants, and partners, and communicate complex technical information clearly to multidisciplinary and senior audiences.

Nice to have

• Direct experience supporting first-in-human and subsequent clinical studies.

Culture & Benefits

• Hybrid work model with three office days per week.
• Work across a growing portfolio of development-stage therapeutics and influence both portfolio selection and program development.
• Equity, comprehensive benefits, and generous perks are offered in addition to base salary.
• hirify.global promotes a diverse and inclusive workplace and is an equal opportunity employer.