Scientist (Genome Editing)

Location: On-site in Cambridge, Massachusetts, United States

Base pay: $88,000–$124,000 per year

Company

hirify.global advances biomedical science and the understanding and treatment of disease through human genetics and partnerships with MIT, Harvard, and affiliated hospitals.

What you will do

• Design, execute, and analyze experiments evaluating base-editing, prime-editing, and other precision genome-editing technologies across therapeutic programs.
• Lead genome-wide off-target and specificity-profiling workstreams using methods including CIRCLE-seq, ONE-seq, CHANGE-seq BE, and related approaches.
• Design and execute high-throughput screens to identify and prioritize editing strategies and guide/pegRNA designs for neurologic and metabolic disease programs.
• Develop and analyze high-throughput sequencing assays, including library preparation and amplicon sequencing, and interpret editing and specificity data.
• Contribute to preclinical strategy, editor and modality selection, study design, platform-based IND planning, and evaluation of external technologies.
• Prepare reports, figures, regulatory materials, and FDA-engagement documents; collaborate with internal and external partners, maintain rigorous documentation, and mentor junior scientists and trainees.

Requirements

• PhD in molecular biology, genetics, genome engineering, biomedical engineering, or a related field with 0+ years of experience; or a related Master’s degree with 5+ years of relevant industry or research experience; or a related Bachelor’s degree with 7+ years of progressive, relevant industry experience.
• Proven deep expertise in base editing and/or prime editing.
• Experience with unbiased genome-wide specificity-profiling methods such as GUIDE-seq, Digenome-seq, CIRCLE-seq, ONE-seq, CHANGE-seq, CHANGE-seq BE, PEG-seq, or related methods is strongly preferred.
• Experience designing and executing high-throughput lentiviral screens is strongly preferred.
• Proficiency in high-throughput sequencing library preparation and amplicon sequencing, with the ability to analyze and interpret sequencing data independently or through computational collaboration.
• Strong record of rigorous, reproducible experimental work; publications and/or conference presentations are preferred.
• Excellent written and verbal communication skills, including translating complex genome-editing science for cross-functional and non-specialist audiences.
• Ability to collaborate in a large, cross-functional, deadline-driven research group while executing independently and managing shifting priorities.

Nice to have

• Familiarity with preclinical or IND-enabling study design and the translational path for gene-editing therapeutics.
• Interest or prior experience in neurologic and metabolic disease biology.

Culture & Benefits

• Full-time, 40-hour-per-week position in a dynamic, cross-functional research environment.
• Medical, dental, vision, life, and disability insurance.
• 401(k) retirement plan, flexible spending and health savings accounts.
• At least 13 paid holidays, winter closure, paid time off, parental and family care leave, and an employee assistance program.
• Equal opportunity employment and reasonable accommodation support for the application and interview process.