Scientist (Viral Gene Delivery)

Location: San Francisco, California, United States; on-site

Salary: $120K–$215K per year plus equity

Company

hirify.global is a frontier research lab developing brain-computer interfaces that combine high-bandwidth brain interaction with advanced AI.

What you will do

• Design, build, and test AAV and other viral vectors for CNS gene delivery, including serotype selection, cargo and regulatory element design, dose, and administration route.
• Design, run, and interpret in vivo studies in rodents and, where appropriate, large animal models.
• Evaluate brain delivery routes, including viral vectors paired with focused ultrasound blood-brain barrier opening.
• Build or adapt assays to quantify delivery, expression, cell-type specificity, and tolerability in brain tissue.
• Evaluate emerging delivery technologies and make data-driven recommendations for the team’s delivery strategy.

Requirements

• Ph.D. or equivalent experience leading research projects end-to-end in bioengineering, neuroscience, virology, cell biology, molecular biology, or a related field.
• Hands-on experience designing and testing AAV or other viral vectors in vivo to target the central nervous system.
• Expertise in developing or optimizing gene delivery modalities.
• Experience developing and executing assays to evaluate gene delivery and expression in brain tissue.
• Experience designing and executing in vivo studies and interpreting delivery and expression results.
• Experience using focused ultrasound to open the blood-brain barrier or otherwise facilitate delivery to the brain.
• Experience working on unusual or complex delivery-related problems.
• Experience collaborating and communicating effectively on multidisciplinary teams.
• Interest in working on fast-paced frontier scientific and technical problems.

Nice to have

• Experience advancing a vector through preclinical translation or into the clinic.
• Familiarity with CMC, scale-up, or GMP manufacturing considerations for viral vectors.
• Expertise in AAV virology or capsid engineering.
• Experience working with large animal models.
• Familiarity with non-viral delivery technologies.
• Experience sourcing, evaluating, or in-licensing delivery technologies through external collaboration.

Culture & Benefits

• Work in a multidisciplinary Delivery team partnering with bioengineering, neuroscience, and in vivo teams.
• Collaborate with protein engineers, cell and synthetic biologists, machine learning engineers, physicists, and neuroscientists.
• Work on next-generation neurotechnology intended to support safe and effective human translation.
• Compensation includes equity.