Principal Engineer, Microsoft 365 and Copilot Platforms (AI)

Location: Boston, MA. Hybrid work is available remotely up to two days per week, or on-site five days per week with ad hoc flexibility.

Salary: $144,000–$216,000 annual base salary, plus eligibility for an annual bonus and annual equity awards.

Company

Vertex is a global biotechnology company investing in scientific innovation and patient outcomes.

What you will do

• Lead technical delivery for Microsoft 365 Modern Work and enterprise AI initiatives, including technical design, change control, implementation, and operational coordination.
• Provide technical leadership across Microsoft Teams, SharePoint Online, OneDrive, Exchange, Microsoft Copilot, GitHub Copilot, Copilot Studio, agents, and AI governance.
• Lead business escalations, critical incident management, root cause analysis, and troubleshooting.
• Drive automation and continuous improvement across supported platforms.
• Serve as the technical authority by challenging solution designs, coordinating working sessions, engaging stakeholders, and driving solutions.
• Create and maintain environment documentation, standard operating procedures, and knowledge-base articles.

Requirements

• Principal- or lead-level knowledge of Microsoft Teams, SharePoint Online, OneDrive, Exchange, Microsoft 365 governance, Entra ID, security, and compliance dependencies.
• Deep practical knowledge of Microsoft Copilot, Copilot Studio, Power Automate, Power Apps, enterprise agents, AI governance, and adoption controls including Agent 365.
• Extensive experience delivering and governing enterprise Microsoft 365 Modern Work capabilities, including complex technical delivery, operational escalations, and cross-functional implementation.
• Ability to convert business requirements into secure technical designs and completed delivery outcomes.
• Experience balancing business enablement, user experience, and operational sustainability in a regulated enterprise environment.
• Experience leading complex technical escalations and coordinating execution across internal teams, control functions, vendors, and managed service providers.
• Excellent written and verbal communication skills for explaining technical decisions, risks, and recommendations to technical and non-technical audiences.
• Strong analytical and problem-solving skills, including comfort with ambiguity, incomplete information, shifting priorities, and multiple dependencies.
• Bachelor’s degree or equivalent in Information Systems, Computer Science, Engineering, Business, or a related discipline, or equivalent professional experience.

Nice to have

• Experience implementing Microsoft Copilot, Copilot Studio, enterprise agents, AI governance, or related AI productivity capabilities.
• Experience working in a regulated enterprise environment and partnering with security, privacy, legal, compliance, identity, and operational teams.

Culture & Benefits

• Approximately 60% hands-on work and 40% technical leadership.
• Continuous learning focused on AI, technology, automation, and industry trends.
• Medical, dental, and vision benefits; generous paid time off; and week-long summer and winter company shutdowns.
• Educational assistance, student loan repayment, commuting subsidy, charitable donation matching, and 401(k).
• Equal employment opportunity, reasonable accommodations, and an inclusive workplace.