Senior Bioinformatics Engineer

Location: US - California - San Diego; hybrid role.

Base salary: $129,400–$194,000 per year, plus eligible variable cash compensation and potential equity.

Company

hirify.global develops genomic technology supporting research, clinical genomics, disease detection, diagnosis, and treatment.

What you will do

• Lead end-to-end verification of complex data analysis software in multidisciplinary teams.
• Partner with engineering, bioinformatics, pipeline, and scientific stakeholders to convert requirements into traceable automated verification workflows.
• Design and build scalable platform capabilities, including plugin frameworks, workflow orchestration, CI/CD, and observability.
• Lead through code and design reviews while promoting maintainable architecture and engineering standards.
• Improve documentation, reproducibility, automation, and developer productivity across approximately 30 repositories, hundreds of test suites, and dozens of engineers.

Requirements

• At least 5 years of related experience with a Bachelor’s degree, 3 years with a Master’s degree, a PhD without experience, or equivalent work experience.
• Significant Python experience, including Django, REST APIs, pytest, and modern tooling.
• Hands-on experience with CI/CD, Git/GitHub, Docker, and Linux/Unix environments.
• Strong software architecture and system design skills, with the ability to own technical direction across teams.

Nice to have

• Deep experience with NGS or secondary analysis, such as variant calling, methylation, or alignment, and knowledge of oncology, molecular biology, bioinformatics, or related biology.
• Familiarity with DRAGEN or comparable secondary analysis platforms.
• Experience running workloads on HPC clusters and AWS.
• Experience with workflow orchestration beyond CI/CD, such as Airflow, Nextflow, or similar tools.
• Hands-on use of AI coding agents, IDE harnesses, or LLM tool integrations, including MCP, for feature delivery, engineering workflow automation, or internal tooling.
• Experience using AI for code review, test design, refactoring, or documentation, supported by delivered projects or workflows.
• Open-source contributions in bioinformatics or developer tools.

Culture & Benefits

• Work on clinical genomics software whose tests gate releases used in hospitals and laboratories worldwide.
• Collaborative and inclusive environment focused on openness, alternative perspectives, and belonging.
• Benefits include genomics sequencing access, family planning support, health, dental and vision coverage, retirement benefits, and paid time off.
• Employee Resource Groups provide career development, cultural awareness, and social responsibility opportunities.
• Clear potential progression to Staff Engineer depending on interests.
• Background checks are conducted after a conditional offer; generative AI is prohibited during the application and interview process. This role is not eligible for visa sponsorship.