Front Line Manufacturing Manager (Bulk Drug Substance - Upstream) - Night Shift (Biotechnology)

Location: On site in Holly Springs, North Carolina, United States. Night shift follows a 2-2-3, 12-hour rotation from 5:45 PM to 6:15 AM.

Salary: $106,148–$143,612 per year.

Company

hirify.global is a biotechnology company developing medicines and operating an advanced drug substance manufacturing facility using disposable technologies, stainless-steel equipment, industry 4.0 capabilities, and sustainability initiatives.

What you will do

• Lead on-shift floor operations and experienced manufacturing associates producing GMP drug substance.
• Maintain a safe, compliant production environment and ensure adherence to cGMP, CFR, gowning, and aseptic requirements.
• Supervise, coach, hire, train, evaluate, and develop manufacturing staff while driving team performance.
• Oversee critical manufacturing processes, equipment setup, execution, completion, production schedules, and maintenance activities.
• Identify and implement process improvements, CAPAs, change controls, and solutions to complex operational problems.
• Collaborate with QA/QC, Facilities and Engineering, PPIC, Manufacturing, Process Development, and Regulatory teams.

Requirements

• Doctorate degree; or a master’s degree plus 3 years of manufacturing or operations experience; or a bachelor’s degree plus 5 years; or an associate degree plus 10 years; or a high school diploma/GED plus 12 years.
• Previous experience directly managing people or leading teams, projects, programs, or resource allocation.
• Experience in manufacturing or operations, preferably in biotechnology, pharmaceuticals, or a highly regulated cGMP environment.
• Strong leadership, coaching, mentoring, conflict resolution, analytical problem-solving, project management, and technical communication skills.
• Working knowledge of manufacturing processes, regulatory requirements, Microsoft tools, EBR/MES, Delta V, and electronic quality systems.

Nice to have

• Bachelor’s degree in life sciences or engineering.
• Experience with biotechnology or pharmaceutical plant startup and upstream or downstream operations.
• Five years of process experience in a cGMP manufacturing facility.
• Three or more years in a production Area Lead, Specialist, or Manager role.

Culture & Benefits

• Career-development resources to expand skills and expertise.
• Diverse and inclusive workplace where employees are encouraged to contribute ideas.
• Total rewards package covering health, financial, work-life balance, and career benefits.
• Full-time employment with a structured night-shift schedule.

Hiring process

• Applicants can complete a Workday Career Profile and upload an updated resume or work history.
• Internal applicants must generally have been in their current position for at least 18 months and meet performance eligibility requirements.