Supervisor, CGMP Manufacturing – Downstream (Peptide Manufacturing)

Location: On-site in Menlo Park, California, United States

Salary: $100,000–$120,000 per year for US-based candidates, plus equity; location-based ranges may apply outside the US.

Company

Hims & Hers is a public health and wellness platform delivering personalized healthcare access from diagnosis through treatment and delivery.

What you will do

• Lead upstream cGMP peptide manufacturing, including SPPS, cleavage, filtration, precipitation, and crude peptide isolation.
• Direct downstream operations including preparative HPLC purification, lyophilization, final isolation, packaging, and labeling.
• Manage production schedules across multiple products, balancing equipment capacity, staffing, materials, and QC turnaround.
• Oversee equipment readiness, qualification, preventive maintenance, vendor coordination, and real-time floor troubleshooting.
• Lead deviation and failed-batch investigations, root-cause analysis, CAPAs, process improvements, scale-up, tech transfer, and PPQ campaigns.
• Lead, coach, train, and develop chemists, operators, and technicians while maintaining GMP qualifications and shift coverage.

Requirements

• Bachelor’s degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline.
• At least 3 years of cGMP manufacturing experience in pharmaceutical, biopharmaceutical, or peptide manufacturing.
• Hands-on experience with preparative HPLC purification and lyophilization.
• At least 1 year of experience leading or supervising production teams.
• Strong knowledge of cGMP batch execution, deviations, CAPAs, data integrity, and manufacturing documentation.
• Strong problem-solving, communication, and organizational skills in a fast-moving manufacturing environment.

Nice to have

• Commercial-scale SPPS, downstream prep HPLC, and lyophilization experience.
• Experience with process validation, PPQ campaigns, and tech transfer of peptide products into GMP manufacturing.
• Experience with budget oversight, capital projects, vendor management, staffing, MES, electronic batch records, and continuous improvement.

Culture & Benefits

• Competitive salary and equity compensation for full-time roles.
• Unlimited PTO, company holidays, and quarterly mental health days.
• Medical, dental, vision, and parental leave benefits.
• Employee Stock Purchase Program and 401(k) with employer matching.
• Offsite team retreats and a focus on safety, ethics, wellness, accountability, and belonging.