Computational Chemist (AI)

Location: Remote, U.S. only; domestic travel required 20–40% of the time

Salary: $180K–$250K plus equity

Company

Builds and deploys AI scientist agents that accelerate scientific research and the development of new medicines.

What you will do

• Improve AI agent performance on hit-to-lead chemistry tasks, including SAR analysis, structure-based design, and synthetic feasibility analysis.
• Design benchmarks and acceptance criteria for chemistry-focused agent workflows.
• Partner with medicinal chemists at pharmaceutical and biotech organizations to integrate AI agents into discovery workflows.
• Assess AI-generated chemistry for structural soundness, failure modes, and practical actionability.
• Collaborate with Forward Deployed Engineers and Computational Biologists across client accounts.
• Support engagement scoping, success metrics, and technical evaluations with go-to-market teams.

Requirements

• Ph.D. in Computational Chemistry, Medicinal Chemistry, Organic Chemistry, or a related field.
• 5+ years of industry experience, ideally within a pharmaceutical or biotech sponsor organization.
• Experience with lead optimization campaigns from hit identification through candidate nomination.
• Deep knowledge of cheminformatics tools such as RDKit, Schrödinger, or MOE.
• Experience integrating ADMET and DMPK data into design decisions and proficiency in Python.
• Experience across multiple therapeutic areas, with comfort working through ambiguity and rapid iteration.

Culture & Benefits

• Fast-moving, mission-driven environment focused on applying AI to scientific discovery.
• Full healthcare coverage for employees and dependents.
• Paid parental leave, family support, fertility coverage, and mental health support.
• 401(k) matching, commuter benefits, pet care support, and quarterly health and wellness benefits.
• Paid meals during office days and late work, plus regular team off-sites and company events.