3 дня назад
Associate Scientist/Scientist I, Molecular Function
132 000 - 167 000$
Мэтч & Сопровод
Для мэтча с этой вакансией нужен Plus
Описание вакансии
Текст:
TL;DR
Associate Scientist/Scientist I, Molecular Function (Protein Engineering/Phage Display): Building high-throughput platforms and running display campaigns to identify and measure protein-protein interactions for AI-driven antibody and protein design with an accent on library construction, assay development, and NGS-based screening. Focus on designing selection strategies, validating binding hits, and generating quantitative, model-ready datasets in collaboration with ML, protein design, automation, and bioinformatics scientists.
Location: Emeryville, California, United States; on-site
Hiring salary range: $132,000–$167,000 USD per year
Company
is an AI biology lab building foundation models for molecules to support advances in medicine, agriculture, and protein design.
What you will do
- Build high-throughput platforms for identifying and measuring protein-protein interactions.
- Lead phage display campaigns from library construction and panning through NGS and hit validation.
- Design and troubleshoot selection strategies, including antigen selection, library quality control, and stringency selections.
- Build and validate assays and define controls and quality criteria for screening output.
- Plan targets, assays, and readouts with ML and protein design scientists.
- Convert binding data into datasets suitable for model training and evaluation.
Requirements
- MS with 3+ years of industry experience or PhD with 0–2 years of industry experience in molecular biology, biochemistry, protein engineering, biophysics, immunology, or a related discipline.
- Deep hands-on experience with phage display and antibody discovery is required.
- Strong molecular biology skills for library construction.
- Understanding of NGS-based screening and quantitative analysis of sequencing data.
- Strong analytical and troubleshooting skills with careful attention to detail and record-keeping.
- Ability to work on-site in Emeryville, California.
Nice to have
- Experience with therapeutic antibody optimization, including affinity maturation, developability, and format engineering.
- Experience measuring binding kinetics and affinity with SPR or BLI/Octet, and performing epitope mapping.
- Familiarity with yeast, mammalian, ribosome, or mRNA display systems.
- Familiarity with Hamilton or Tecan laboratory automation platforms.
- Experience moving assays or platforms into routine use, with familiarity with LIMS and data or metadata schemas.
Culture & Benefits
- High-growth work at the intersection of AI and biology.
- Equity participation and competitive compensation.
- 401(k) with a strong employer match.
- Health, dental, and vision insurance.
- Generous paid time off and a commitment to work-life balance.
- Professional development opportunities.
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