Senior Research Scientist (CRISPR/iPSC)

Location: On-site in Burlington, Massachusetts, United States

Salary: $115,000–$161,667 per year

Company

hirify.global’s Genomics Platform conducts research and develops high-throughput functional genomics and screening capabilities.

What you will do

• Design and execute pooled CRISPR knockout, activation, interference, and base-editing screens.
• Lead library design, cloning, virus production, transduction optimization, and screening execution across iPSCs, primary cells, and other complex models.
• Manage iPSC maintenance, expansion, 2D and 3D culture, and differentiation into neurons, cardiomyocytes, immune cells, and other lineages.
• Develop cell-to-data workflows integrating automated liquid handling, high-throughput sequencing, single-cell RNA sequencing, and imaging readouts.
• Collaborate with investigators and computational biologists to interpret results, validate hits, and perform secondary and arrayed assays.
• Mentor Research Associates and oversee laboratory logistics, reagent scaling, equipment maintenance, and safety compliance.

Requirements

• PhD in Molecular Biology, Genetics, Bioengineering, or a related field with 5+ years of postdoctoral or industry experience, or a Master’s degree with 8+ years of specialized experience.
• Proven hands-on expertise in pooled CRISPR screening, including library cloning, lentiviral production, and screen execution.
• Deep experience with iPSC culture, differentiation, and long-term 2D and 3D cultures.
• Expertise in molecular cloning, including Gibson assembly or Golden Gate, NGS library preparation, and qPCR/ddPCR.
• Familiarity with gRNA design, screening data quality control, and collaboration with data scientists on hit analysis.
• Ability to manage multiple screening projects, communicate complex functional genomics findings, and contribute to scientific publications.

Nice to have

• Experience with automated liquid-handling platforms such as Hamilton, Beckman, or Agilent.

Culture & Benefits

• Full-time employment with a comprehensive benefits package.
• Medical, dental, vision, life, and disability insurance.
• 401(k), flexible spending and health savings accounts.
• Paid holidays, winter closure, paid time off, and parental and family care leave.
• Employee assistance program and support for scientific career development.