Senior/Executive Director, Reverse Translation, Oncology Translational Research (Oncology)

Location: Hybrid role based in Spring House, Pennsylvania; Cambridge, Massachusetts; or San Diego, California, United States

Base pay: $196,000–$342,700 per year

Company

Johnson & Johnson develops healthcare, Innovative Medicine, and MedTech solutions focused on preventing, treating, and curing complex diseases.

What you will do

• Lead a laboratory-based reverse-translation group across the oncology therapeutic area.
• Run independent studies on disease biology, mechanisms of action, resistance, and combination strategies.
• Translate clinical observations into testable laboratory hypotheses and insights for active programs and the pipeline.
• Build and manage a wet-lab team, consolidate scientists across disease-area programs, and develop expertise across anticancer mechanisms.
• Own omics, functional and perturbation biology, in vitro, in vivo, and organoid platforms for drug and sample characterization.
• Partner with Discovery, Clinical, Medical Affairs, and Commercial teams while contributing to translational strategy, publications, and portfolio decisions.

Requirements

• PhD, MD, or MD/PhD in cancer biology, molecular biology, immunology, pharmacology, or a related field.
• 10+ years of experience for Senior Director or 12+ years for Executive Director in oncology discovery or translational research.
• Hands-on laboratory leadership experience, including building and leading wet-lab teams.
• Broad mechanism-of-action expertise and a record of converting clinical observations into testable laboratory hypotheses.
• Experience with omics, functional characterization platforms, matrix collaboration, and multiple disease areas.
• Strong first- or last-author publication record and scientific communication skills.

Nice to have

• Experience with multiomics, perturbation biology, organoid models, and computational data integration.
• Experience mining shelved programs for portfolio-relevant insights.
• Experience designing combination and resistance-reversal strategies across modalities.
• Experience partnering with Medical Affairs and Commercial teams on lifecycle-focused science.

Culture & Benefits

• Inclusive work environment guided by the company’s Credo and focused on patient impact.
• Participation in a consolidated retirement plan and 401(k) savings plan, subject to plan terms.
• Eligibility for the long-term incentive program.
• Vacation, sick time, holidays, parental, caregiver, bereavement, volunteer, and military spouse leave programs.