3 дня назад
Senior Research Associate (Bioanalytical & Molecular Assays)
Мэтч & Сопровод
Для мэтча с этой вакансией нужен Plus
Описание вакансии
Текст:
TL;DR
Senior Research Associate (Bioanalytical & Molecular Assays) (mRNA therapeutics): Developing and validating molecular bioanalytical assays for RNA quantitation and clinical PK/PD programs with an accent on qPCR, ddPCR, genomic sample processing, and GCLP compliance. Focus on optimizing fit-for-purpose methods, reviewing analytical data, transferring assays into clinical laboratories, and applying automation and Generative AI-enabled workflows.
Location: Oxford, England, United Kingdom; 70% in-office work model
Company
develops mRNA-based therapeutics and vaccines using molecular science, delivery technology, and manufacturing capabilities.
What you will do
- Perform bioanalytical assays for RNA quantitation in biological matrices using gel electrophoresis, ddPCR, qPCR, RT-qPCR, and related molecular and cellular biology techniques.
- Develop, qualify, validate, optimize, and transfer phase-appropriate assays supporting clinical pharmacokinetic and pharmacodynamic analyses.
- Isolate genomic DNA and RNA, review raw analytical data and reports, and ensure data integrity, scientific rigor, and regulatory compliance.
- Partner with internal and external laboratories, Clinical Operations, Sample Management, and development teams to support clinical trial sample journeys and laboratory manuals.
- Maintain equipment, critical reagents, SOPs, electronic laboratory notebooks, and supporting documentation.
- Improve laboratory efficiency and data interpretation through digital tools, automation, and Generative AI-enabled scientific workflows.
Requirements
- M.S. with at least 5 years of experience or B.S. with at least 8 years of experience in molecular biology or a relevant scientific discipline.
- Experience performing clinical molecular assays in bioanalytical and GCLP/GLP environments.
- Hands-on knowledge of molecular biology and nucleic acid characterization techniques, including gel electrophoresis, capillary electrophoresis, and qPCR.
- Knowledge of GCLP requirements, analytical science regulations, and current industry expectations.
- Ability to communicate program objectives and data analysis and present findings to colleagues and stakeholders.
Nice to have
- Experience with next-generation sequencing and genomics.
Culture & Benefits
- Collaborative, fast-paced environment focused on learning, scientific curiosity, and continuous improvement.
- Healthcare and voluntary benefit programs.
- Fitness, mindfulness, mental health, and family-building support.
- Paid vacation, bank holidays, volunteer days, sabbatical, global recharge days, and year-end shutdown.
- Savings and investment programs plus location-specific benefits.
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