Clinical Lead Early Development and Experimental Therapeutics - Oncology

Location: Hybrid role based in Cambridge, Massachusetts or Morristown, New Jersey, United States

Company

R&D-driven, AI-powered biopharma company developing medicines and vaccines through immunoscience, translational research, and clinical development.

What you will do

• Design and lead early clinical development programs for oncology assets, including small molecules, monoclonal antibodies, antibody-drug conjugates, and immune cell engagers.
• Develop and oversee First-In-Human through phase 2a studies, including natural history, mechanistic, signal-seeking, proof-of-mechanism, and proof-of-concept trials.
• Make clinical decisions related to protocol design, dose escalation, safety, dose selection, and early Go/No Go assessments.
• Provide medical monitoring, review adverse events, interpret clinical and translational data, and oversee study safety.
• Coordinate regulatory, safety, biostatistics, biomarker, pharmacokinetic, clinical operations, and CRO activities.
• Review and author clinical protocols, informed consent forms, investigator brochures, regulatory documents, key results memos, and clinical study reports.

Requirements

• M.D. or equivalent required.
• At least 3 years of clinical research experience.
• English required for global cross-functional, CRO, investigator, and regulatory interactions.
• Experience with early clinical trials, preferably First-In-Human and phase 1/2a studies, and interpretation of preclinical or biomarker data.
• Experience leading cross-functional teams and providing medical safety oversight for clinical trials.
• Knowledge of GCP practices, translational medicine, clinical trial design, and biomedical research.

Nice to have

• MD plus PhD or equivalent bench science experience.
• Experience with combination therapies, cytoplasmic signaling pathways, late-phase clinical trials, or global pharmaceutical development.
• Experience using emerging digital and AI-driven tools and solutions.
• Postgraduate residency training and laboratory research experience.

Culture & Benefits

• Collaborative, future-focused environment spanning research, clinical development, regulatory, safety, and operations.
• Opportunities for professional growth through promotion or lateral career moves.
• Health and wellbeing benefits, including healthcare, prevention, and wellness programs.
• At least 14 weeks of gender-neutral parental leave.
• Work with AI, data, and digital platforms to accelerate drug development and incorporate patient insights into study design.