7 дней назад
Senior Scientist (Mass Spectrometry-Based Proteomics)
Мэтч & Сопровод
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Описание вакансии
Текст:
TL;DR
Senior Scientist (Mass Spectrometry-Based Proteomics) (Biotechnology/Proteomics): Developing high-throughput mass spectrometry-based proteomics workflows and screening platforms to support target identification and drug discovery with an accent on automated sample preparation, LC-MS/MS analysis, and quantitative proteomics. Focus on designing and optimizing screening workflows, analyzing high-dimensional proteomics data, and generating insights into mechanism of action, target engagement, and selectivity.
Location: Thousand Oaks, California, United States
Company
is a biotechnology company developing and delivering medicines for serious illnesses across oncology, inflammation, general medicine, and rare disease.
What you will do
- Design, develop, and optimize high-throughput mass spectrometry-based proteomics workflows and screening platforms for drug discovery.
- Execute automated sample preparation and LC-MS/MS analyses across a broad range of high-throughput proteomics assays.
- Collaborate with chemistry, biology, and disease area teams as a technical and scientific subject matter expert.
- Analyze proteomics data and generate insights into mechanism of action, target engagement, and selectivity.
- Present research findings and communicate plans, results, and analyses to cross-functional teams.
- Maintain accurate documentation of experiments, protocols, and analyses.
Requirements
- PhD, PharmD, or MD with relevant experience; alternatively, a master’s degree with 4 years of directly related experience or a bachelor’s degree with 6 years of directly related experience.
- Doctorate-level training in proteomics, chemoproteomics, biochemistry, chemistry, or a related discipline.
- Strong experience developing mass spectrometry-based proteomics assays, operating advanced platforms such as Orbitrap Astral, and analyzing proteomics data.
- Experience with sample preparation miniaturization and automation platforms.
- At least 3 years of experience in the biotechnology or pharmaceutical industry.
- Strong quantitative and computational expertise in high-dimensional proteomics data analysis, with excellent collaboration and communication skills.
Nice to have
- Knowledge of targeted protein degradation or E3 ligase biology.
Culture & Benefits
- Comprehensive medical, dental, vision, life, disability, and flexible spending benefits.
- Retirement and savings plan with company contributions.
- Annual discretionary bonus program and stock-based long-term incentives.
- Award-winning time-off plans.
- Flexible work models where applicable.
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