2 дня назад
Scientist, ADC In Vivo Pharmacology
79 400 - 132 400$
Мэтч & Сопровод
Для мэтча с этой вакансией нужен Plus
Описание вакансии
Текст:
TL;DR
Scientist, ADC In Vivo Pharmacology (ADC/Oncology): Executing in vivo oncology studies for antibody-drug conjugate and other large- and small-molecule programs with an accent on efficacy, pharmacodynamic, tolerability, and mechanistic studies. Focus on tumor models, dosing and sample collection, study documentation, data interpretation, and compliance with animal welfare requirements.
Location: San Diego, California, United States; on-premise work
Annual base salary: $79,400–$132,400, plus eligibility for a 7.5% bonus target.
Company
conducts pharmaceutical research and development, including oncology discovery and preclinical development.
What you will do
- Execute in vivo oncology studies supporting ADC, large-molecule, and small-molecule discovery programs.
- Perform tumor implantation and measurement, animal monitoring, IV, PO, subQ, and IP dosing, clinical observations, and sample collection.
- Support efficacy, tolerability, pharmacodynamic, dose-response, schedule optimization, and combination studies.
- Prepare and follow study protocols, dosing schedules, randomization plans, and sample collection timelines.
- Maintain compliant electronic study records and support data review, graphical summaries, and interpretation.
- Coordinate with project leads, vivarium operations, pathology, toxicology, bioanalytical, pharmacodynamic, pharmacokinetic, and external teams.
Requirements
- Bachelor’s degree in biology, pharmacology, animal science, cancer biology, or a related discipline with relevant research experience.
- Hands-on experience conducting rodent in vivo studies and proficiency with tumor implantation, measurements, dosing, monitoring, sample collection, and documentation.
- Working knowledge of oncology pharmacology, including tumor growth inhibition, response assessment, dose scheduling, tolerability, and pharmacodynamic endpoints.
- Strong attention to detail, organization, communication, collaboration, and ability to manage concurrent study activities.
- Ability to follow protocols, identify technical or animal welfare concerns, and work under IACUC, biosafety, and internal requirements.
- Permanent work authorization in the United States is required; U.S. work visa sponsorship is not available.
Nice to have
- Experience with ADC, targeted therapy, immuno-oncology, or combination oncology programs.
- Familiarity with ADC payload potency, linker stability, antigen expression, exposure-response relationships, and tolerability liabilities.
- Experience with ex vivo tissue processing, necropsy, flow cytometry sample preparation, molecular endpoints, or in vitro assays.
- Studylog or similar electronic data system experience and AALAS certification or equivalent animal-care training.
Culture & Benefits
- On-premise laboratory and vivarium work with occasional weekend work.
- Relocation assistance may be available based on business needs and eligibility.
- 401(k) matching and an additional retirement savings contribution.
- Paid vacation, holidays, personal days, caregiver/parental leave, and medical leave.
- Medical, prescription drug, dental, and vision coverage.
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