Scientist, ADC In Vivo Pharmacology

Location: On premise in San Diego, California, United States; permanent U.S. work authorization required.

Salary: $79,400–$132,400 annual base salary, plus eligibility for a 7.5% performance bonus.

Company

hirify.global is a pharmaceutical research and development organization advancing oncology and antibody-drug conjugate programs.

What you will do

• Execute in vivo oncology studies for ADC discovery programs using syngeneic, cell line-derived, and patient-derived xenograft models.
• Perform tumor measurements, animal monitoring, test article administration, clinical observations, and sample collection.
• Support studies evaluating efficacy, tolerability, pharmacodynamic biomarkers, dose response, schedule optimization, and combination strategies.
• Prepare and follow protocols, dosing schedules, randomization plans, and sample collection timelines.
• Maintain compliant study records and assist with data review, graphical summaries, and preliminary interpretation.
• Coordinate with pathology, toxicology, bioanalytical, pharmacodynamic, pharmacokinetic, vivarium, and external partner teams.

Requirements

• Bachelor’s degree in biology, pharmacology, animal science, cancer biology, or a related discipline with relevant research experience.
• Hands-on experience conducting rodent in vivo studies and proficiency with tumor implantation, tumor measurement, dosing, monitoring, sample collection, and documentation.
• Working knowledge of oncology pharmacology, including tumor growth inhibition, response assessment, dose scheduling, tolerability, and pharmacodynamic endpoints.
• Ability to follow protocols precisely, identify technical or animal welfare concerns, and escalate issues appropriately.
• Strong organization, attention to detail, communication, and collaboration skills in a matrixed scientific environment.
• U.S. work authorization by any employer is required; U.S. work visa sponsorship is not available.

Nice to have

• Experience with ADC, targeted therapy, immuno-oncology, or combination oncology programs.
• Knowledge of payload potency, linker stability, antigen expression, exposure-response relationships, and ADC tolerability liabilities.
• Experience with ex vivo tissue processing, biomarker collection, necropsy, flow cytometry sample preparation, or molecular endpoint workflows.
• Familiarity with Studylog or similar electronic in vivo study management systems.
• AALAS certification or equivalent animal care and use training.

Culture & Benefits

• On-premise work with after-hours availability as needed to maintain study integrity.
• Relocation assistance may be available based on business needs and eligibility.
• 401(k) matching and additional retirement savings contributions.
• Paid vacation, holidays, personal days, caregiver/parental leave, and medical leave.
• Medical, prescription drug, dental, and vision coverage.