Scientist / Sr. Scientist In Vivo Translational Sciences (Biotech)

Location: San Francisco Bay Area, California, United States; the role requires working in a lab/vivarium for the majority of working hours and supporting weekend study needs.

Salary: Scientist II, In Vivo Pharmacology: $148,400–$190,300 per year; Senior Scientist I, In Vivo Pharmacology: $171,400–$219,700 per year.

Company

hirify.global develops cell rejuvenation approaches intended to restore cell health and resilience and address disease, injury, and age-related disability.

What you will do

• Lead the full lifecycle of in vivo pharmacology studies, from design and protocol development through dosing, monitoring, tissue collection, analysis, interpretation, and reporting.
• Select pharmacodynamic and target-engagement readouts and contribute to translational strategies for target validation and candidate progression.
• Develop, characterize, and implement mouse and rat models, including fibrosis and other age-related pathologies.
• Execute rodent studies, including dosing, anesthesia, aseptic survival surgeries, necropsy, tissue processing, and occasional ex vivo analyses.
• Evaluate new technologies and best practices to improve in vivo study efficiency and quality while maintaining complete electronic lab notebook documentation.
• Collaborate with discovery biology, pharmacology, assay sciences, DMPK, technology development, and external CRO partners.

Requirements

• Ph.D. in biological sciences with 3–5 years of industry experience for Scientist level or 6+ years for Senior Scientist level in drug discovery and development.
• Extensive hands-on expertise in rodent research, including dosing routes, anesthesia, surgical procedures, necropsy, and tissue processing in mice and rats.
• Experience with molecular and cell biology techniques, including RNA/DNA extraction, PCR, Western blot, ELISA, and small-molecule or biologic assays.
• Strong analytical, problem-solving, organizational, communication, and collaboration skills.
• Commitment to animal welfare, 3Rs-centered experimental design, IACUC-approved protocols, and ethical study conduct.
• Ability to work in a lab/vivarium environment for most working hours, including weekend study support.

Nice to have

• Experience with small molecules, biotherapeutics, nucleic acid therapeutics, and gene therapy.
• Experience analyzing fibrosis, inflammation, metabolic disorders, neurodegeneration, or other age-related diseases in animal models.

Culture & Benefits

• Collaborative environment focused on scientific excellence, learning, belonging, and inclusion.
• Emphasis on ownership, continuous improvement, professional growth, and creative problem-solving.
• Equal employment opportunity and a commitment to a diverse and inclusive workplace.