10 дней назад
Scientist, Rare Disease Biology
Мэтч & Сопровод
Для мэтча с этой вакансией нужен Plus
Описание вакансии
Текст:
TL;DR
Scientist, Rare Disease Biology (Immunology/Cell Biology): Investigating rare disease mechanisms and therapeutic targets through in vitro and ex vivo studies, human data integration, and computational analysis with an accent on autoimmune disease biology, fibroblast activation, tissue remodeling, and inflammatory signaling. Focus on designing complex disease models, integrating experimental findings with genetics, omics, and clinical datasets, and generating data-driven recommendations for research portfolios.
Location: Thousand Oaks, California, United States
Company
is a biotechnology company developing medicines for serious illnesses across oncology, inflammation, general medicine, and rare disease.
What you will do
- Design, execute, analyze, and interpret in vitro and ex vivo studies of rare disease mechanisms and therapeutic hypotheses.
- Investigate Thyroid Eye Disease biology, including immune dysregulation, fibroblast activation, tissue remodeling, and inflammatory signaling.
- Integrate experimental results with literature, human genetics, clinical observations, and other data sources to generate mechanistic insights.
- Apply computational and data analysis tools to evaluate datasets and support therapeutic target prioritization.
- Collaborate with disease biologists, computational scientists, translational researchers, academic partners, and external experts.
- Present findings, contribute to target and portfolio reviews, and maintain accurate scientific documentation.
Requirements
- PhD in Immunology, Cell Biology, Molecular Biology, Pharmacology, Biomedical Sciences, or a related discipline; alternatively, a master's degree with 2 years of scientific research experience or a bachelor's degree with 4 years of scientific research experience.
- Experience designing and executing cell-based, molecular, and biochemical assays.
- Experience with fibroblast biology, tissue remodeling, fibrosis, stromal cells, extracellular matrix biology, or related disease mechanisms.
- Experience with primary human cells, tissue-derived cultures, organoids, or advanced in vitro disease models.
- Strong data analysis and interpretation skills, including work with complex biological datasets and experimental or computational approaches.
- Ability to communicate scientific concepts clearly and collaborate effectively in matrixed research environments.
Nice to have
- Experience with transcriptomic, proteomic, imaging, or other data-rich approaches.
- Experience integrating omics, human genetics, clinical datasets, and scientific literature.
- Familiarity with AI-enabled scientific tools, computational workflows, image analysis, or advanced data analytics.
Culture & Benefits
- Collaborative, innovative, science-based research environment.
- Health, dental, vision, life, disability, and flexible spending benefits.
- Retirement and savings plan with company contributions.
- Annual bonus program and stock-based long-term incentives.
- Paid time off, work-life balance support, and career development opportunities.
- Flexible work models where applicable.
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