1 день назад
Immunoassay Senior Scientist
Мэтч & Сопровод
Для мэтча с этой вакансией нужен Plus
Описание вакансии
Текст:
TL;DR
Immunoassay Senior Scientist (Drug Discovery/Biotechnology): Designing, developing, validating, and interpreting sensitive singleplex and multiplex immunoassays to support screening cascades for small-molecule and oligonucleotide therapeutics with an accent on target engagement, pharmacodynamic markers, and robust bioanalytical data. Focus on optimizing assay platforms, integrating in vitro and in vivo pharmacology, overseeing CRO data generation, and guiding compound progression through multidisciplinary DMTA cycles.
Location: Cambridge, UK; hybrid working is offered, with work required from the Babraham Research Campus offices and laboratories based on business needs and role requirements.
Company
is a global biopharmaceutical company developing therapies for patients with serious and rare diseases.
What you will do
- Design, develop, optimize, validate, troubleshoot, and interpret sensitive singleplex and multiplex immunoassays for drug discovery screening cascades.
- Generate pharmacodynamic, target engagement, pathway modulation, and immunogenicity data for small-molecule and oligonucleotide therapeutics.
- Support early pharmacokinetic and pharmacodynamic assessments, compound profiling, DMTA cycles, lead optimization, and candidate selection.
- Partner with Chemistry, DMPK, Target Discovery, New Projects, Biology, and in vivo pharmacology teams to align assay strategy with project milestones.
- Oversee immunoassay data generation at CROs and critically assess scientific quality, interpretation, and delivery.
- Mentor junior scientists, improve experimental capabilities, maintain SOPs and ELN records, and present data packages at project and biology meetings.
Requirements
- Degree with extensive immunoassay or early-stage target engagement and pharmacodynamic assay development experience in a drug discovery environment; typically at least 5 years of relevant experience.
- Demonstrated experience with ELISA, HTRF, AlphaLISA, MSD, Luminex, fit-for-purpose method validation, assay troubleshooting, and bioanalytical data interpretation.
- Experience contributing to DMTA cycles and collaborating with Chemistry, DMPK, and multidisciplinary project teams.
- Experience managing or collaborating with CROs, including biomarker assay development and compound logistics.
- Working knowledge of assay automation, liquid handling, plate-based workflows, GraphPad Prism, ELNs, and scientific databases.
- Ability to work from the Babraham Research Campus in South Cambridge under the role’s hybrid working arrangement.
Nice to have
- Experience with ultra-sensitive platforms such as Simoa, flow cytometry, high-content imaging, oligonucleotide modalities, or broader biochemical, cellular, and biophysical assays.
- Formal line management experience and knowledge of emerging immunoassay technologies, automated liquid handling, and ultra-sensitive detection platforms.
Culture & Benefits
- Work in new laboratories and offices at the Babraham Research Campus, a bioscience innovation and collaboration hub.
- Flexible work schedules with purposeful in-person collaboration and hybrid-friendly technology support.
- Competitive retirement benefits, global equity awards, and participation in the Employee Stock Purchase Plan.
- Professional development through the Learning Institute, external programs, LinkedIn Learning, role-specific training, and AI-powered learning tools.
- Global recognition programs and Employee Resource Groups.
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