gRNA Process Development Scientist (CRISPR)

Location: Boston, MA, USA; candidates should live within a commutable distance of Boston. Full-time, Monday-Friday, 8am-5pm, with overtime as needed.

Salary: USD 32.00-41.00 per hour

Company

hirify.global is an international life sciences company providing analytical testing, laboratory, genomics, pharmaceutical, and agroscience services.

What you will do

• Develop gRNA drug substance manufacturing processes and controls for clinical-stage programs.
• Execute solid-phase synthesis, purification, scale-up, and process transfer experiments for oligonucleotide drug substances.
• Perform routine analytics using HPLC, UV-Vis, chromatography systems, gel electrophoresis, and NanoDrop.
• Prepare buffers, reagents, and stock solutions according to established recipes and SOPs.
• Compile and present experimental data to team members and stakeholders.
• Maintain laboratory records and equipment, order materials, support troubleshooting, and uphold laboratory safety standards.

Requirements

• B.S. or M.S. degree in chemistry, chemical engineering, biochemistry, or a related field, plus at least two years of relevant laboratory industry experience.
• Experience with oligonucleotide synthesis and purification equipment.
• Experience with Tangential Flow Filtration (TFF) is required.
• Experience with Akta chromatography systems, Agilent U/HPLC, gel electrophoresis, and NanoDrop.
• Experience with good documentation practices and electronic laboratory notebooks such as Benchling.
• Authorization to work in the United States indefinitely without restriction or sponsorship is preferred.

Nice to have

• Background in CRISPR gRNA development.
• Experience with gRNA or longmer synthesis and purification development.

Culture & Benefits

• Professional growth opportunities and support for entering and advancing in the biopharmaceutical industry.
• Work-life balance and a supportive team environment.
• Medical, dental, and vision coverage.
• Life and disability insurance.
• 401(k) with company match, paid vacation, and paid holidays.
• Eligibility for yearly goal-based bonuses and merit-based increases.