Senior Principal Scientist, Data Science RWE (Real-World Evidence)

Location: Hybrid role based in Titusville, New Jersey, United States of America. Additional posting locations include Cambridge, Massachusetts; Raritan, New Jersey; and Spring House, Pennsylvania.

Salary: $137,000–$235,750 per year, plus eligibility for incentive, retirement, and paid-leave programs.

Company

Johnson & Johnson MedTech and Innovative Medicine develop healthcare treatments, technologies, and solutions across the spectrum of patient care.

What you will do

• Lead a portfolio of real-world evidence projects as a hands-on scientific and technical leader.
• Develop best practices and maintain reusable tools that accelerate real-world data science delivery.
• Design and execute end-to-end RWE studies, including research questions, feasibility, study design, analysis, programming, and interpretation.
• Develop methods to mitigate observed and unobserved bias in external control arm, hybrid control, and comparative effectiveness studies.
• Generate actionable insights from post-hoc RCT analyses, observational databases, and literature reviews for regulatory interactions.
• Partner with therapeutic-area data scientists, mentor team members, and deliver protocols, statistical analysis plans, analysis-ready data, tables, and figures.

Requirements

• Ph.D. in epidemiology or biostatistics.
• Expert coding skills in R, Python, or SAS.
• At least 5 years of relevant experience in biopharma, RWE consulting, or related healthcare industries.
• Hands-on experience extracting, cleaning, and analyzing data, including methods for mitigating confounding and selection bias.
• Expertise with multiple real-world data sources, including EHR, insurance claims, and registry data; familiarity with clinical trial data structures.
• Excellent interpersonal, communication, presentation, and mentoring skills.

Nice to have

• Familiarity with drug discovery and clinical development.
• Subject matter knowledge in oncology, immunology, or neuroscience.
• Experience producing regulatory-grade evidence and responding to agency reviews and comments.

Culture & Benefits

• Inclusive work environment guided by the company’s Credo and equal opportunity principles.
• Retirement pension and 401(k) savings plans.
• Long-term incentive program eligibility.
• Paid vacation, sick time, holidays, personal and family time, parental, bereavement, caregiver, volunteer, and military spouse leave.