Research Leader (DMPK)

Location: Cambridge, Massachusetts, United States; hybrid work with attendance in the office 3 days per week

Company

hirify.global applies frontier AI and machine learning to drug discovery, developing predictive and generative models for molecular design and therapeutic research.

What you will do

• Design and implement stage-appropriate, AI-first DMPK strategies integrated with quantitative pharmacology and project objectives.
• Design screening cascades and mechanistic experiments to support data-driven drug discovery decisions.
• Integrate DMPK, pharmacodynamic, and toxicological data to predict doses and safety windows.
• Define quantitative pharmacology strategies with Pharmacology Leads and collaborate with Preclinical, Clinical, Chemistry, and Technology teams.
• Optimise datasets and molecule design using physico-chemical and biotransformation knowledge.
• Author DMPK sections of regulatory documents and advance methods for human PK prediction.

Requirements

• PhD in Pharmaceutical Science, Pharmacy, Chemistry, or a related field.
• 7–10+ years of professional DMPK experience in a biotech or pharmaceutical setting.
• Experience developing DMPK and quantitative pharmacology packages for early clinical development.
• Experience authoring and reviewing regulatory documents and partnering with Preclinical and Clinical teams.
• In-depth knowledge of biotransformation, PK modelling, and scaling of ADME properties.
• Ability to work from the Cambridge, MA office 3 days per week.

Nice to have

• Experience with peptides and other new modalities.
• Advanced knowledge of PK/PD modelling.
• Understanding of machine learning techniques.
• Familiarity with Python and R.

Culture & Benefits

• Hybrid collaboration model focused on knowledge sharing and in-person relationships.
• Culture guided by thoughtful, brave, determined, and collaborative work.
• Emphasis on inclusion, continuous professional development, shared learning, and employee support.
• Equal employment opportunity and workplace accommodation support.