Principal Engineer, Lentivirus Downstream Process Development (Biotechnology)

Location: Onsite in Somerset, New Jersey, United States. Applicants must be authorized to work in the United States; employment eligibility is verified through E-Verify.

Base pay: $146,410–$192,164 USD annually, plus performance-based bonus and/or equity for eligible roles.

Company

hirify.global is a biotechnology company developing cell therapies, including CAR-T, TCR-T, NK-cell therapies, and lentiviral vector technologies.

What you will do

• Design, optimize, and scale downstream purification processes for lentiviral vectors.
• Build mechanistic, hybrid, and in silico process models using engineering principles, machine learning, and data analytics.
• Develop downstream workflows covering clarification, depth filtration, centrifugation, chromatography, and tangential flow filtration.
• Translate bench-scale processes to GMP manufacturing through simulation, laboratory work, technology transfer, and clinical production support.
• Implement advanced process control strategies, including model predictive control and state estimators.
• Lead scientists, author technical and regulatory documents, and collaborate with upstream, analytical, CMC, project, and external manufacturing teams.

Requirements

• PhD preferred, or MS, in Chemical Engineering, Biomedical Engineering, Bioprocessing Engineering, or a related field.
• At least 8 years of experience with a PhD or 10 years with an MS in biotech or pharmaceutical process development or manufacturing.
• Strong knowledge of bioprocess modeling and simulation, biomolecule interactions, and process engineering.
• Experience with Python and MATLAB, plus deep technical expertise in purification, chromatography, and TFF.
• Strong understanding of GMP manufacturing requirements and CMC strategies for clinical trials, with deep knowledge of lentiviral vector technologies.
• English is required, and applicants must already be authorized to work in the United States.

Nice to have

• Experience developing vector processes for in vivo CAR-T generation and systemic delivery.
• Experience with large-scale purification processes above 50 liters.
• Mandarin language skills.

Culture & Benefits

• Medical, dental, and vision insurance with a 401(k) company match that fully vests on day one.
• Eight weeks of paid parental leave after three months of employment.
• Paid vacation, personal and sick time, floating holidays, and eleven company holidays.
• Additional spending accounts, disability and life insurance, commuter benefits, family-care resources, and well-being programs.
• Benefits are available exclusively to permanent full-time employees; contractors are not eligible.