Principal Scientist, Upstream Process Science (Biotechnology)

Location: On site in Louisville, Colorado, United States; Monday–Friday during standard business hours, with manager-approved flexibility. Work takes place in laboratory and cleanroom environments, with occasional travel of up to 10%.

Annual base pay: $150,000–$165,000, depending on qualifications, experience, and geographic location. The role is also eligible for a discretionary bonus and equity award.

Company

hirify.global is a commercial-stage biotechnology company developing immunotherapies, cell therapies, cancer vaccines, and treatments for infectious diseases.

What you will do

• Lead upstream process development for microbial and cell culture production of whole-cell products, viral vectors, recombinant monoclonal antibodies, Fc-fusion proteins, and other biologics.
• Provide technical leadership for batch, fed-batch, and perfusion processes, including inoculum expansion and bioreactor operations across multiple cell lines.
• Manage daily team activities, including hiring, training, coaching, and performance monitoring.
• Coordinate process development, process improvement, scale-up, technology transfer, and GMP manufacturing support.
• Guide risk assessments, Design of Experiments, process characterization, validation, and process monitoring activities.
• Prepare and approve protocols, reports, SOPs, deviation investigations, and process-related regulatory submissions; present results to cross-functional teams and senior management.

Requirements

• Ph.D. in Cell Biology, Microbiology, Biology, life sciences, or a related field with 6+ years of relevant experience; or an MSc with 9+ years; or a bachelor’s degree with 12+ years.
• Direct experience in upstream biopharmaceutical process development and/or GMP manufacturing operations.
• Expertise in upstream production processes and statistical Design of Experiments.
• Advanced knowledge of microbial, cell culture, and harvest operations affecting product quality.
• Knowledge of cell and molecular biology, immunology, and/or virology, plus familiarity with downstream purification.
• Strong technical writing and communication skills, including experience preparing SOPs, validation documentation, reports, and materials supporting FDA and EMA filings.

Nice to have

• Previous supervisory experience.

Culture & Benefits

• Collaborative environment with opportunities to work across different areas of the company.
• Professional development opportunities in a growing publicly traded biopharmaceutical company.
• Medical, dental, vision, health and financial wellness programs, and an Employee Assistance Program.
• Life, disability, flexible spending, retirement, education savings, legal, identity protection, pet insurance, and employee discount benefits.
• Paid time off, including 11 holidays; exempt employees are eligible for unlimited PTO.