Executive Director / Vice President, Biology & Translational Pharmacology (AI)

Location: Emeryville, California, United States; on-site. Applicants must have ongoing authorization to work in the United States without employer sponsorship.

Hiring salary range: $270,000–$340,000 USD per year, plus equity participation.

Company

hirify.global is an AI biology lab building foundation models for biological molecules and developing AI-designed gene editing therapeutics.

What you will do

• Build and lead a liver biology and translational pharmacology organization, including management of program and in vivo pharmacology leaders.
• Lead scientific strategy and execution for 2–3 liver-directed genetic medicine programs targeting severe inborn metabolic diseases.
• Direct cross-functional therapeutic teams spanning genome editing, protein engineering, delivery, pharmacology, bioanalytics, CMC, regulatory, and preclinical development.
• Define resourcing, critical-path activities, timelines, risks, and experiments needed for development candidates and IND-ready data packages.
• Guide rodent and NHP pharmacology studies covering model selection, dosing, biodistribution, editing activity, durability, biomarkers, target engagement, efficacy, and tolerability.
• Present program strategy, data, risks, and recommendations to executives, board members, advisors, partners, investors, and collaborators.

Requirements

• Advanced degree such as PhD, MD, DVM, or PharmD in pharmacology, molecular biology, genetics, physiology, hepatology, bioengineering, medicine, or a related discipline.
• PhD in a related discipline with 12+ years of biopharma R&D experience and a strong record in genetic medicines, liver biology, translational pharmacology, and preclinical development.
• Track record of advancing multiple therapeutic programs from concept through development candidate nomination; experience with IND-enabling studies or clinical development is strongly preferred.
• Deep expertise in genetic medicines or advanced modalities, liver and metabolic disease, rare liver diseases, lipid biology, hepatology, fibrosis biology, or metabolic liver disease.
• Experience designing and interpreting in vivo pharmacology studies, including PK/PD, biodistribution, dose response, target engagement, biomarkers, durability, efficacy, and tolerability.
• Ability to lead multidisciplinary and matrixed teams, with working knowledge of IND-enabling requirements, toxicology, CMC, bioanalytics, and regulatory expectations.

Nice to have

• Direct genome editing experience or familiarity with nucleases, base editors, prime editors, and recombinases.
• Experience translating human genetics into disease biology, pharmacology, biomarkers, and development strategy.

Culture & Benefits

• High-growth opportunity focused on the future of protein design and therapeutic development.
• Competitive compensation with equity participation.
• 401(k) with a strong employer match.
• Health, dental, and vision insurance.
• Generous paid time off, work-life balance, and professional development opportunities.

Hiring process

• Employment requires verification of identity and United States work eligibility.
• Employer sponsorship is not available now or in the future for this position.