Senior Director, Global HEOR, Hemoglobinopathies

Location: Boston, MA, United States. Hybrid schedule allows remote work up to two days per week, or on-site work five days per week.

Base salary: $238,400–$357,600 annually, plus eligibility for an annual bonus and annual equity awards.

Company

Vertex is a global biotechnology company focused on scientific innovation and therapies for serious diseases.

What you will do

• Lead the HEOR strategy for hemoglobinopathy assets from early development through launch and post-launch lifecycle stages.
• Serve as the HEOR disease-area lead and represent HEOR across cross-functional and cross-regional teams.
• Oversee evidence generation plans, outcomes research studies, cost-effectiveness analyses, budget impact models, and related deliverables, including work for Casgevy.
• Integrate HEOR evidence into health technology assessment submissions and support access to marketed products across regions.
• Apply best practices to the design, execution, analysis, and dissemination of HEOR studies while maintaining high research quality standards.
• Manage HEOR staff responsible for hemoglobinopathy assets and collaborate with commercial, medical, clinical, and market access functions.

Requirements

• Advanced degree such as PhD, MD, Master's, MPH, or PharmD in a relevant discipline.
• Typically 12 years of experience in health economics and outcomes research or a related field, including 5 years of supervisory or management experience.
• Extensive peer-reviewed publication record covering patient-reported outcomes, observational research, and health economic modeling.
• Experience developing global HEOR strategies, executing studies, and understanding clinical development strategies and trial designs.
• Strong communication, presentation, technical, analytical, and stakeholder management skills in complex matrixed environments.
• Understanding of the pharmaceutical legal and regulatory environment, compliance, and research ethics.

Nice to have

• Market access experience, including payer submissions and payer interaction in the United States and other markets.

Culture & Benefits

• Continuous learning opportunities focused on advances in AI, technology, automation, and industry trends.
• Medical, dental, and vision benefits with paid time off and week-long summer and winter company shutdowns.
• Educational assistance programs, including student loan repayment.
• Commuting subsidy, matching charitable donations, and 401(k) benefits.
• Equal employment opportunity and reasonable accommodations for qualified applicants.