Senior / Principal ML Biophysicist

Location: San Francisco Bay Area, on-site

Salary: $200,000–$270,000 per year, plus equity

Company

hirify.global is a frontier research lab developing brain-computer interfaces that combine biological systems with artificial intelligence.

What you will do

• Build scalable pipelines for protein structure modeling, molecular dynamics, and downstream machine learning integrations.
• Architect tools and workflows for simulating, analyzing, and interpreting biomolecular dynamics-to-function relationships.
• Collaborate with wet-lab scientists to define optimization objectives and encode domain-specific priors and constraints.
• Prototype, benchmark, and validate modeling frameworks using internal and public datasets.
• Develop machine learning frameworks that incorporate first-principles scientific models.
• Prototype novel algorithms and contribute to the long-term research roadmap and discovery workflows.

Requirements

• Strong grounding in deep learning, protein structure modeling, and molecular dynamics.
• Working knowledge of transfer-learning strategies.
• Proficiency in Python, PyTorch, and JAX, with experience writing clean, reproducible, production-grade code.
• Experience bridging machine learning and experimental science using sparse, noisy, or high-cost data.
• Collaborative, systems-level mindset.

Nice to have

• Familiarity with neuroscience.
• Familiarity with language or state-space models.

Culture & Benefits

• Interdisciplinary collaboration across molecular engineering, synthetic biology, neuroscience, physics, engineering, and data science.
• Opportunities to work on high-bandwidth, less-invasive brain-computer interface technologies.
• Equity included in the compensation package.
• Equal opportunity employment and reasonable accommodations for applicants with disabilities.