Senior / Principal Scientist Lung Modeling (Biotech)

TL;DR

Senior / Principal Scientist (Lung Modeling): Designing and developing advanced complex in vitro models (CIVM) of lung systems to support drug safety and efficacy assessments with an accent on microphysiological systems (MPS) and bioengineering. Focus on building airway and alveolar organoids, air-liquid interface cultures, and organ-on-chip platforms to predict pharmacodynamic responses.

Location: Onsite in South San Francisco, California, USA

Salary: $120,700 - $262,900

Company

A member of the Roche Group, hirify.global is a biotechnology pioneer dedicated to discovering and developing medicines for serious and life-threatening diseases.

What you will do

• Develop and characterize advanced lung in vitro models, including airway/alveolar organoids and organ-on-chip systems.
• Drive laboratory workflows for modeling healthy and diseased lung environments, incorporating vascular or stromal components.
• Provide technical guidance and scientific mentorship to junior team members to foster a high-performing lab environment.
• Collaborate with internal research, translational medicine, and drug discovery units at hirify.global and Roche.
• Evaluate external technologies and manage collaborations with academic institutions or CROs.
• Publish research findings in peer-reviewed journals and present at professional forums.

Requirements

• Ph.D. in bioengineering, biomedical engineering, biology, pharmacology, chemical engineering, or a related field.
• Senior Scientist: 0-5 years of post-PhD experience; Principal Scientist: 5+ years of post-PhD experience.
• Proven expertise in developing 3D lung tissue models, organoids, or microphysiological systems (MPS).
• Deep technical mastery of lung biology and mechanisms of lung diseases.
• Expert hands-on experience with cells of pulmonary origin or iPSC-derived lung cell cultures.
• Must be based in or able to work onsite in South San Francisco, CA.

Nice to have

• Toxicology experience focusing on leveraging CIVMs to predict safety.
• Experience with 3D co-cultures and 3D vasculature.
• Proficiency in various omics approaches to study phenotypes in complex models.
• Excellent light microscopy and imaging skills.

Culture & Benefits

• Opportunity to work at the forefront of the biotechnology industry with a pioneer in the field.
• Collaborative and dynamic team environment focused on groundbreaking science.
• Competitive salary and discretionary annual bonus based on performance.
• Comprehensive corporate benefits package.
• Strong emphasis on professional growth and scientific innovation.