Senior Bioinformatics Scientist (Cancer Genomics)

Location: San Carlos, California, United States

Salary: $130,700–$163,400 USD annually, plus eligible bonus, equity awards, and benefits.

Company

hirify.global develops cell-free DNA testing and personalized genetic diagnostics for oncology, women’s health, and organ health.

What you will do

• Develop, train, and evaluate machine learning models for cancer detection in the minimal residual disease setting.
• Lead research analyses from ideation through implementation, troubleshooting, feature development, and performance evaluation.
• Connect wet-lab experimental design with computational analysis as assay requirements evolve.
• Maintain rigorous quality control across high-volume sequencing data from multiple cohorts, vendors, and clinical protocols.
• Communicate findings and model performance to technical and cross-functional stakeholders.
• Help establish standards for code quality and reproducibility.

Requirements

• Ph.D. in bioinformatics, computer science, engineering, biochemistry, or a related field with a focus on cancer epigenomics/genomics and 0–3 years of professional experience, or a master’s degree with 4–6 years of experience.
• Strong understanding of high-throughput DNA sequence data analysis, including mapping, sequence alignment, and variant calling workflows.
• Experience with algorithm development, statistical methods, and analysis of biological data.
• Experience developing core machine learning models, including generalized linear models, kernel methods, tree-based algorithms, and neural networks.
• Strong programming skills with Python, Linux command-line tools, shell scripting, NumPy, Matplotlib, and Pandas.
• Ability to collaborate with computational and experimental scientists and communicate results to technical and non-technical audiences.

Nice to have

• Familiarity with TCGA, COSMIC, or OncoKB databases.
• Interest in teaching and learning new computational methods and biology.

Culture & Benefits

• Collaborative, cross-functional environment with statisticians, geneticists, physicians, laboratory scientists, and software engineers.
• Medical, dental, vision, life, and disability insurance for eligible employees and dependents.
• 401(k) plan with company match, paid time off, and company holidays.
• Annual performance incentive bonus and long-term equity awards.
• Wellness, work-life, commuter, fertility care, pregnancy, and baby bonding benefits.