Director, Pharmacometrics, Clinical Pharmacology (Pharmaceuticals)

TL;DR

Director, Pharmacometrics, Clinical Pharmacology (Pharmaceuticals): Leading the design and execution of modeling and simulation approaches for drug development programs with an accent on MIDD, PK/PD, and regulatory strategy. Focus on shaping dose selection and trial design for therapies targeting rare diseases.

Location: Must be based in the United States

Company

A pharmaceutical partner company focusing on the development of therapies for rare diseases.

What you will do

• Develop and execute end-to-end modeling and simulation strategies across early- and late-stage clinical development programs.
• Lead PK/PD, population PK, exposure-response, and disease progression modeling activities.
• Define pharmacometric strategies for regulatory submissions, including dose justification and trial design support.
• Act as the subject matter expert and scientific authority in Model-Informed Drug Development (MIDD).
• Collaborate with clinical and regulatory teams to integrate modeling outputs into broader development plans.
• Guide exploratory and advanced modeling approaches, including QSP and empirical frameworks.

Requirements

• PhD or PharmD in Pharmaceutical Sciences, Clinical Pharmacology, Mathematics, Statistics, Engineering, or related field.
• 6+ years of relevant industry experience in pharmacometrics and model-based drug development.
• Strong expertise in NLME methods, population PK/PD modeling, and clinical trial simulation.
• Hands-on experience with NONMEM and R.
• Deep understanding of clinical pharmacology principles and rare disease therapeutic areas.
• Must be based in the United States.

Culture & Benefits

• Competitive base salary with short-term and long-term incentive compensation, including equity.
• Comprehensive medical, dental, and vision insurance for employees and dependents.
• Retirement savings plan with employer matching contributions.
• Generous paid time off and flexible vacation policies.
• Flexible work arrangements with a remote-based structure.
• Wellness programs and employee support resources.