Post-Doctoral Associate (Proteomics)

TL;DR

Post-Doctoral Associate (Proteomics): Leading cutting-edge projects in nanoflow hydrogen/deuterium exchange-mass spectrometry (nHDX-MS) for cancer biology, epigenetics, and chemical biology research with an accent on characterizing protein-ligand/protein-protein interactions and identifying binding sites. Focus on developing methods for challenging targets and advancing analytical capabilities using Electron Transfer Dissociation (ETD) for single-residue resolution.

Location: On-Site in Cambridge, MA, USA

Salary: $70,000–$92,667/yr

Company

The hirify.global of MIT and Harvard is a world-leading non-profit research organization dedicated to realizing the promise of the post-genomic era for human benefit.

What you will do

• Apply automated nHDX-MS workflows to characterize protein-ligand and protein-protein interactions, including epitope mapping.
• Identify binding sites for drugs and metabolites within complex mixtures.
• Develop methods for successful interrogation of challenging targets (membrane proteins, transcription factors, macromolecular assemblies).
• Advance analytical capabilities of nHDX-MS by leveraging Electron Transfer Dissociation (ETD) for single-residue resolution.
• Lead high-impact collaborative research at the intersection of cancer biology, epigenetics, and chemical biology.

Requirements

• Ph.D. in analytical chemistry, chemical biology, biochemistry, or a closely related field required.
• Fundamental understanding of molecular biology highly desired.
• Proven track record of scientific excellence, evidenced by peer-reviewed publications.
• Meticulous attention to detail, strong critical thinking, and exceptional organizational skills.
• Excellent verbal and written communication skills.
• Hands-on experience in HDX-MS sample preparation, data generation, and interpretation is an advantage.
• Proficiency in programming (R or Python) and experience analyzing large-scale datasets is an advantage.

Culture & Benefits

• Opportunity to work alongside a premier network of scientists from Broad, MIT, Harvard, and affiliated hospitals.
• Competitive benefits package including medical, dental, vision, life, and disability insurance.
• 401(k) retirement plan, flexible spending and health savings accounts.
• At least 13 paid holidays, winter closure, paid time off, and parental and family care leave.
• Interdisciplinary and highly collaborative research environment.