Principal Scientist (Translational Clinical Biomarkers - Hematology/Oncology)

Location: Hybrid; primary location in North Wales, Pennsylvania, USA. The posting is for US and Puerto Rico residents only. Domestic relocation is listed.

Salary: $190,800–$300,300 annual base salary for the primary location; annual bonus and long-term incentive may apply.

Company

hirify.global is a biopharmaceutical company developing medicines and advancing clinical research across oncology and other therapeutic areas.

What you will do

• Develop and lead integrated translational and clinical biomarker strategies for hematology programs, especially CML, BCR::ABL1-driven disease, and other myeloid malignancies.
• Translate disease biology, therapeutic mechanisms, molecular heterogeneity, clonal evolution, treatment response, and resistance into actionable biomarker plans.
• Define biomarkers supporting proof of biology, target engagement, dose and regimen selection, patient selection, molecular response, resistance characterization, and go/no-go decisions.
• Integrate molecular response and MRD assessments, mutation profiling, clinical outcomes, treatment history, preclinical pharmacology, and longitudinal clinical data.
• Lead interpretation of complex biomarker and clinical datasets and provide strategic recommendations to cross-functional development teams and senior stakeholders.
• Partner with Discovery, Clinical Development, Quantitative Sciences, Regulatory, Data Science, Clinical Operations, Pathology, Diagnostics, and external scientific collaborators.

Requirements

• Ph.D., M.D., or equivalent advanced scientific degree in hematology, oncology, molecular biology, translational medicine, pharmacology, or a related discipline.
• Significant experience developing and executing translational or clinical biomarker strategies in hematology or oncology drug development.
• Strong understanding of hematologic malignancies, molecular drivers, treatment response, resistance mechanisms, and clonal evolution.
• Experience translating disease biology and therapeutic mechanisms into biomarker strategies that inform clinical development decisions.
• Working knowledge of molecularly targeted therapies and the relationships between pharmacology, disease biology, resistance, clinical endpoints, and development strategy.
• Experience interpreting molecular and cellular biomarker data using one or more of NGS, quantitative PCR, molecular response or MRD assays, flow cytometry, gene-expression profiling, or other genomic approaches.
• Experience leading cross-functional scientific activities in a matrixed organization and influencing decisions without direct authority.
• Strong analytical, problem-solving, communication, scientific writing, and presentation skills, including the ability to synthesize multidimensional datasets into decision-oriented conclusions.
• Working knowledge of biostatistics, bioinformatics, quantitative sciences, and integrated biomarker data analysis, with a strategic focus on rigorous, scalable, actionable evidence.

Nice to have

• Direct experience with CML, BCR::ABL1 biology, tyrosine kinase inhibitor development, and mechanisms of sensitivity and resistance.
• Experience with other myeloid malignancies, including myeloproliferative neoplasms and acute myeloid leukemia.
• Experience evaluating kinase domain mutations, compound mutations, co-occurring somatic alterations, treatment response, and resistance.
• Familiarity with CML molecular response monitoring, BCR::ABL1 International Scale reporting, major molecular response, deep molecular response, and treatment-response guidelines.
• Experience integrating resistance profiling, pharmacology, longitudinal clinical molecular data, genomic and cellular biomarkers, and clinical outcomes.
• Experience supporting targeted or emerging therapeutic modalities, late-stage or registrational programs, companion diagnostics, regulatory interactions, mentoring, or external scientific collaborations.

Culture & Benefits

• Hybrid work arrangement with a regular daytime shift.
• Comprehensive medical, dental, vision, insurance, retirement, and 401(k) benefits.
• Paid holidays, vacation, compassionate leave, and sick days.
• Collaborative and inclusive environment focused on scientific rigor, respectful challenge, and cross-functional problem-solving.
• Travel requirement: 10%; visa sponsorship is not available.

Hiring process

• Applications are accepted through the hirify.global careers portal; the posting is effective until the day before the stated November 13, 2026 end date.
• Accommodation support is available during the hiring process for eligible US and Puerto Rico applicants.