Senior Principal Scientist (Cell and Gene Therapy)

Location: Remote, Americas; listed location: Waltham, Massachusetts, United States

Base salary: $179,000–$212,000 per year, excluding potential incentive compensation and equity.

Company

hirify.global is a global biotherapeutics company developing therapies across immunology, hematology, cardiovascular and metabolic, respiratory, and transplant areas using plasma fractionation, recombinant protein, and cell and gene therapy platforms.

What you will do

• Provide senior scientific and technical leadership for CMC strategy supporting innovative biologics.
• Assess process and analytical development, characterization, manufacturing, technology transfer, stability, control strategy, and lifecycle management activities.
• Develop evidence-based, fit-for-purpose recommendations that balance scientific, regulatory, quality, supply, timeline, and business requirements.
• Serve as a subject matter expert for cell and gene therapy and cell-based therapeutic platforms.
• Oversee technical work with CDMOs, CROs, technology providers, and strategic collaborators, including scope definition, deliverable review, investigations, and risk mitigation.
• Partner with cross-functional and international teams while strengthening scientific standards, technical practices, knowledge sharing, and mentoring.

Requirements

• 8+ years of relevant industry experience in CMC, process engineering, pharmaceutical development, biotechnology, chemical manufacturing, process development, manufacturing, or a related technical discipline.
• Direct experience with cell and gene therapy and/or cell-based therapeutic platforms.
• Demonstrated experience in process improvement development and execution, including identifying technical gaps, recommending improvements, and supporting implementation.
• Experience organizing, developing, and deploying best-practice frameworks, processes, tools, and templates aligned with enterprise standards.
• 5+ years of experience in a global matrix organization involving cross-functional, multicultural, and international teams.
• Experience working with external development and manufacturing organizations, including CDMO selection, technical due diligence, technology transfer, governance, and issue resolution.
• Strong understanding of CMC principles across product and process development, analytical and control strategies, manufacturing, technology transfer, stability, regulatory requirements, and lifecycle management.
• Ability to influence technical direction through subject matter expertise, evidence-based recommendations, and collaboration in a global, matrixed pharmaceutical or biotechnology environment.
• Advanced degree in a relevant scientific or engineering discipline preferred; a Bachelor’s degree with significant relevant industry experience will be considered.

Nice to have

• 5+ years of experience in cell and gene therapy, including senior scientific or technical expertise for complex biologic, cell therapy, gene therapy, or other advanced therapeutic programs.
• Familiarity with AAV or other viral vectors, baculovirus-based expression systems, insect cell platforms, oligonucleotides, nucleic acid-based therapeutics, recombinant proteins, or other emerging modalities.

Culture & Benefits

• Full-time employment with benefits information provided through CSL’s candidate resources.
• Work within a global organization serving patients in more than 100 countries.
• Culture focused on inclusion, belonging, curiosity, empathy, collaboration, accountability, and continuous improvement.