Associate Scientist, Post Doc Fellow - Quantitative Biosciences Early Discovery (Biophysics)

Location: Rahway, New Jersey, United States of America

Salary: $82,000–$92,000 per year, plus eligibility for annual bonus and long-term incentive where applicable.

Company

hirify.global is a global biopharmaceutical company conducting industrial research and early-stage drug discovery.

What you will do

• Design and execute methodologies to investigate chemically induced proximity, including molecular glues and heterobifunctional degraders/PROTACs.
• Apply quantitative biochemical, biophysical, and structural methods to study macromolecular complexes, ternary complex formation, and protein–small molecule interactions.
• Own an independent research agenda from hypothesis generation through mechanistic validation within multidisciplinary discovery teams.
• Integrate experimental studies with computational workflows, structural constraints, predictive protein–ligand and protein-complex models, and testable hypotheses.
• Present findings at internal symposia and international conferences and lead publications in peer-reviewed scientific journals.

Requirements

• Currently hold a Ph.D. or receive a Ph.D. no later than spring 2027 in Biochemistry, Biophysics, Pharmacology, Structural Biology, or a related discipline.
• Hands-on experience characterizing protein–ligand and protein–protein interactions using quantitative biophysical methods such as SPR, ITC, MST, BLI, TR-FRET, or fluorescence polarization.
• Experience designing recombinant protein constructs, using expression systems, and performing chromatographic purification.
• Working knowledge and practical experience in biological NMR spectroscopy and/or structural biology techniques.
• Ability to analyze, visualize, and interpret high-resolution protein structures, binding interfaces, and ligand binding modes using molecular modeling software.
• First-author publications in reputable peer-reviewed journals and presentations at scientific conferences.
• Excellent written, verbal, and interpersonal communication skills with the ability to work in collaborative, team-oriented research settings.

Nice to have

• Experience with ternary complex systems, targeted protein degradation, molecular glues, or hit-finding platforms such as FBDD, HTS, or DEL.
• Experience with X-ray crystallography, cryo-EM, or multidimensional BioNMR.
• Familiarity with AI/ML structure prediction tools including AlphaFold, RoseTTAFold, Boltz, or Chai.
• Proficiency in Python or R and exposure to molecular docking, molecular dynamics simulations, or virtual screening.
• Isotopic labeling experience for NMR or structural applications.

Culture & Benefits

• Collaborative, innovation-driven research environment with mentorship from senior scientific leaders.
• Support for high-impact publications, international conference presentations, and development of industrial early-discovery expertise.
• Comprehensive medical, dental, vision, insurance, retirement, and 401(k) benefits.
• Paid holidays, vacation, compassionate leave, and sick days.
• Visa sponsorship is available.
• Travel requirements are 10%; the position is regular employment and flexible work arrangements are not applicable.