Associate Director, Pharmacometrics

Location: Remote/Home-Based in the United States; listed locations are Palo Alto, CA and Philadelphia, PA

Base pay for US-based candidates: $164,000–$246,000 annually, plus potential bonus, equity, and benefits.

Company

hirify.global is a global biopharmaceutical company developing medicines for serious diseases, with a portfolio spanning sleep disorders, epilepsy, oncology, and neuroscience.

What you will do

• Develop pharmacometrics strategies for multiple portfolio programs from research through registration and beyond.
• Design, perform, interpret, and report population PK, PK/PD, and exposure-response analyses.
• Provide hands-on modeling and simulation support for dose selection, optimization, and clinical development.
• Support clinical study protocol design, data analysis, reporting, CSRs, and regulatory documents for Phase 1–4 studies.
• Prepare development plans and regulatory submissions, respond to agency queries, and support inspections.
• Manage pharmacometrics consultants and vendors and contribute to cross-functional Model Informed Drug Development activities.

Requirements

• PhD in pharmaceutical sciences, biomedical engineering, clinical pharmacology, or mathematical/statistical sciences, with 5+ years of experience analyzing clinical pharmacokinetic and pharmacokinetic-pharmacodynamic data.
• Strong understanding of clinical pharmacology, pharmacometrics principles, and the drug development process.
• Experience performing PK/PD modeling and simulation using software such as NONMEM, Monolix, Phoenix WinNonlin, R, GastroPlus, SimCYP, ADAPT, or PK-Sim.
• Ability to work independently and collaboratively in a multidisciplinary team environment.
• Ability to succeed in a fast-paced, highly matrixed work environment.
• Excellent written and oral communication, including presentation skills.
• Ability to embody and model Jazz core values.

Nice to have

• Experience interacting with regulatory agencies.

Culture & Benefits

• Remote/home-based role supporting international drug development programs.
• Cross-functional collaboration in a multidisciplinary and highly matrixed environment.
• US-based employees may receive medical, dental, and vision insurance, a 401(k) retirement savings plan, and flexible paid vacation.
• Potential eligibility for discretionary annual cash bonus or incentive compensation and equity grants.
• Equal opportunity employer.