Associate Director, Clinical Pharmacology, Clinical and Quantitative Pharmacology (mRNA)

Location: Oxford, England, United Kingdom. Hybrid 70/30 work model with 70% in-office collaboration.

Company

hirify.global develops an mRNA technology platform, medicines, and related research, laboratory, and manufacturing capabilities.

What you will do

• Develop fit-for-purpose clinical pharmacology plans covering dose selection and optimization, PK/PD, immunogenicity, pediatric development, and lifecycle requirements.
• Perform and evaluate PK/PD, exposure-response, modeling, and simulation analyses and translate findings into development recommendations.
• Integrate nonclinical, translational, clinical, literature, external, and emerging program data into quantitative evidence for development decisions.
• Partner with Pharmacometrics and Quantitative Systems Pharmacology colleagues on integrated analyses, model interpretation, and program-level decisions.
• Represent Clinical Pharmacology on multidisciplinary program teams and contribute to protocols, INDs, BLA summary documents, briefing books, and regulatory interactions.
• Support mRNA platform development across oncology, immunology, and rare disease, including appropriate use of Generative AI and advanced digital tools under scientific review and governance.

Requirements

• PhD in Clinical Pharmacology, Pharmacometrics, Pharmaceutics, Statistics, Engineering, or a related field, plus at least 5 years of industry experience in clinical pharmacology, DMPK, or Pharmacometrics.
• Practical expertise in quantitative pharmacology, including PK/PD modeling, exposure-response analysis, modeling and simulation, and translational PK/PD, with the ability to evaluate assumptions, results, and limitations.
• Experience integrating nonclinical and clinical evidence for first-in-human predictions, dose selection and optimization, and regulatory decision-making.
• In-depth knowledge of clinical pharmacology, PK/PD principles, drug disposition, ADME, and quantitative translational sciences.
• Proficiency in data analysis, visualization, and pharmacokinetic or modeling software such as R, Phoenix WinNonlin, NONMEM, Monolix, or equivalent tools.
• Strong verbal and written communication skills, independence, and ability to work in a highly matrixed team environment.
• The role may require an enhanced pre-employment check.

Nice to have

• Drug development experience in oncology is strongly preferred.
• Expertise in immune therapeutics and/or rare diseases is a plus.

Culture & Benefits

• In-person collaboration is emphasized through a 70/30 work model, with 70% of work conducted in the office.
• Smoke-free, alcohol-free, and drug-free work environment.
• Healthcare and voluntary benefit programs, fitness, mindfulness, and mental health support.
• Family-building support, including fertility, adoption, and surrogacy benefits.
• Paid vacation, bank holidays, volunteer days, sabbatical, global recharge days, and discretionary year-end shutdown.
• Savings and investment programs plus location-specific benefits.