Lead Bioinformatics Scientist (Oncology)

Location: US Remote

Salary: $130,900–$163,600 USD annually

Company

hirify.global develops cfDNA testing and personalized genetic diagnostics for oncology, women’s health, and organ health.

What you will do

• Lead analytical validation strategy for NGS-based assays, including feasibility and performance studies such as PPA and LoD.
• Drive real-world evidence studies for therapy selection and patient management, from cohort selection through plasma mutation-call analysis.
• Build rapid prototypes, custom analysis pipelines, and tools integrating data from multiple hirify.global products.
• Contribute to production bioinformatics pipelines, regulatory submissions, clinical study reports, and scientific publications.
• Consult internally on bioinformatics methodology and collaborate with assay development, engineering, biostatistics, clinical, commercial, regulatory, and laboratory operations teams.

Requirements

• Master’s degree in bioinformatics or a related field with 10 years of post-graduate experience, or a PhD with 5 years of post-graduate experience.
• Expert knowledge of NGS bioinformatics tools, sequencing QC, secondary analysis, and variant calling.
• Experience with WES, WGS, and targeted sequencing of tissue and cfDNA, including somatic SNVs, indels, CNVs, and fusion calling.
• Working knowledge of statistical methods for assay performance evaluation and ability to collaborate with biostatisticians on study design.
• Strong programming and scripting skills in Python, R, and shell.
• Experience with exploratory data analysis and visualization of complex datasets, translating findings into actionable recommendations.
• Deep understanding of NGS workflows from sample extraction through sequencing and ability to connect bioinformatic findings with wet-lab root causes.
• Ability to communicate technical concepts clearly, work independently, manage multiple objectives and timelines, and adapt when experimental results change the plan.

Nice to have

• Experience with regulated or clinical-grade assay development, including CLIA/CAP requirements and FDA submissions.
• Familiarity with clinical genomics, oncogenic drivers, actionable biomarkers, targeted therapies, and oncology variant interpretation.
• Experience analyzing translational or real-world data and integrating clinical and genomic datasets.

Culture & Benefits

• Work in a small, fast-paced, high-impact interdisciplinary team.
• Eligible employees and dependents receive medical, dental, vision, life, and disability coverage.
• Benefits include free testing for employees and immediate families, fertility care, pregnancy and baby bonding leave, 401(k), commuter benefits, and an employee referral program.
• Equal opportunity employment supports an inclusive workplace for people with diverse backgrounds and perspectives.