Principal Scientist – Translational Medicine (Tumor Microenvironment)

Location: South San Francisco, California, United States; hybrid schedule with onsite presence expected at least 3 days per week.

Salary: $141,500–$262,900 annual hiring range, with a discretionary annual bonus potentially available.

Company

hirify.global develops medicines for serious and life-threatening diseases through research and clinical development.

What you will do

• Develop and execute biomarker strategies for oncology therapeutics from first-in-human through registrational clinical studies.
• Design and implement translational research plans using clinical samples, multi-omic profiling, spatial biology, single-cell technologies, functional immune assays, and emerging AI-enabled analytical approaches.
• Investigate mechanisms of therapeutic response and resistance, tumor microenvironment interactions, immune engagement, and disease evolution, including for T cell engager approaches.
• Collaborate with Research, Clinical Development, Diagnostics, Computational Science, Clinical Pharmacology, Regulatory, Biostatistics, and Companion Diagnostics teams.
• Integrate complex biological datasets to generate clinically actionable insights and support data-driven development decisions.
• Communicate findings through reports, protocols, regulatory documents, publications, presentations, academic collaborations, and scientific conferences.

Requirements

• PhD, MD, or MD/PhD in molecular biology, cancer biology, immunology, computational biology, bioinformatics, or a related field.
• Demonstrated scientific excellence through impactful graduate or postdoctoral research, including first-author publications in high-quality peer-reviewed journals.
• Advanced quantitative and computational expertise, including independent analysis of complex, high-dimensional biological datasets, application of statistical and computational methods, and translation of findings into actionable biological insights.
• Strong scientific curiosity and the ability to independently develop hypotheses and translate complex biological observations into mechanistic insight.
• Excellent written and verbal communication skills for multidisciplinary scientific audiences.
• Ability to work effectively in a collaborative, fast-paced, shifting-priority, dynamic research environment.
• Demonstrated ability to collaborate across diverse scientific disciplines and contribute positively to team culture.

Nice to have

• 3–5 years of experience with translational research approaches, including molecular profiling, multi-omic analyses, spatial biology, single-cell technologies, and/or functional immune assays.
• Interest in innovative computational approaches, including emerging AI-enabled and agentic AI tools, for biomarker discovery, translational insight generation, and data interpretation.
• Strong expertise or scientific interest in tumor microenvironment biology and prostate cancer.
• Knowledge of R and/or Python.

Culture & Benefits

• Collaborative work across research, clinical, computational, regulatory, and statistical disciplines.
• Opportunities to collaborate with academic investigators, clinical trialists, biomarker experts, and key opinion leaders.
• Opportunities to publish research in leading scientific journals and present at national and international conferences.
• Benefits are provided; relocation benefits are not available for this position.
• Equal opportunity employment and applicant accommodations are supported.